Publication Name	World Journal of Hypertension
Manuscript ID	29905
Country	United States

Received	2016-08-30 09:58
Peer-Review Started	2016-09-01 18:17
To Make the First Decision	2016-10-20 08:46
Return for Revision	2016-10-31 09:18
Revised	2016-11-10 02:02
Second Decision	2016-12-12 08:38
Accepted by Journal Editor-in-Chief	2016-12-12 11:06
Accepted by Executive Editor-in-Chief	2016-12-19 11:03
Articles in Press	2016-12-19 11:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-09 15:04
Publish the Manuscript Online	2017-02-16 16:37

ISSN	2220-3168 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Reduction of diastolic blood pressure: Should hypertension guidelines include a lower threshold target?
Manuscript Source	Invited Manuscript
All Author List	Steven Tringali and Jian Huang
Funding Agency and Grant Number
Corresponding Author	Jian Huang, MD, Department of Medicine, Veterans Administration Central California Health Care System, 2615 E Clinton Ave, Fresno, CA 93703, United States. jian.huang@va.gov
Key Words	Blood pressure; Guideline; J-curve; Hypertension; Diastolic pressure
Core Tip	Reduction of diastolic blood pressure to less than 60-80 mmHg appears to lead to adverse cardiovascular events in high risk patient populations. Currently, only two major society guidelines on hypertension include a minimum threshold for diastolic blood pressure. Available studies demonstrating adverse events at lower diastolic blood pressure vary in their cutoff values and patient populations. Randomized controlled trials comparing outcomes across different diastolic blood pressure targets are limited. Hypertension guideline goals should be based on an individual’s age, level of risk, and certain co-morbid conditions, especially coronary artery disease, stroke, chronic kidney disease, and diabetes.
Publish Date	2017-02-16 16:37
Citation	Tringali S, Huang J. Reduction of diastolic blood pressure: Should hypertension guidelines include a lower threshold target? World J Hypertens 2017; 7(1): 1-9
URL	http://www.wjgnet.com/2220-3168/full/v7/i1/1.htm
DOI	http://dx.doi.org/10.5494/wjh.v7.i1.1

Full Article (PDF)	WJH-7-1.pdf
Full Article (Word)	WJH-7-1.doc
Manuscript File	29905-Review.docx
Answering Reviewers	29905-Answering reviewers.pdf
Audio Core Tip	29905-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29905-Conflict-of-interest statement.pdf
Copyright License Agreement	29905-Copyright assignment.pdf
Peer-review Report	29905-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	29905-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	29905-Scientific misconduct check.pdf
Scientific Editor Work List	29905-Scientific editor work list.pdf