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Articles Published Processes
9/15/2014 8:53:00 PM | Browse: 1249 | Download: 1064
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Received |
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2013-03-31 16:14 |
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Peer-Review Started |
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2013-03-31 21:35 |
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To Make the First Decision |
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2013-05-02 10:33 |
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Return for Revision |
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2013-05-17 18:16 |
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Revised |
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2013-06-08 22:08 |
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Second Decision |
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2013-07-17 18:14 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2013-07-18 13:12 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2013-08-21 19:32 |
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Publish the Manuscript Online |
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2013-09-09 09:30 |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Autobiography |
Article Title |
Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Annika Gauss, Robert Ehehalt, Wolf-Dieter Lehmann, Gerhard Erben, Karl-Heinz Weiss, Yvonne Schaefer, Petra Kloeters-Plachky, Adolf Stiehl, Wolfgang Stremmel, Peter Sauer and Daniel Nils Gotthardt |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Deutsche Forschungsgemeinschaft (DFG) |
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Corresponding Author |
Annika Gauss, MD, Gastroenterology and Hepatology Unit, Department of Internal Medicine, University Hospital Heidelberg, INF 410, Heidelberg 69120, Germany. annika.gauss@med.uni-heidelberg.de |
Key Words |
Primary sclerosing cholangitis; Secondary sclerosing cholangitis; Cholangiocellular carcinoma; Phosphatidylcholine; Lysophosphatidylcholine; Bile; Mass spectrometry |
Core Tip |
Based on the idea that unfavorable alterations of biliary phospholipids might play a role in the pathogenesis of sclerosing cholangitis, phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) species profiles were analyzed in endoscopically-acquired intrahepatic bile using nano-electrospray ionization tandem mass spectrometry. The examination of specimens from 14 patients with primary sclerosing cholangitis, 10 patients with secondary sclerosing cholangitis, 11 patients with choledocholithiasis/no biliary disease and 6 patients with cholangiocellular carcinoma revealed strikingly similar PC and LPC species patterns, implicating at the most a minor role of biliary phospholipid changes in sclerosing cholangitis. |
Publish Date |
2013-09-09 09:30 |
Citation |
Gauss A, Ehehalt R, Lehmann WD, Erben G, Weiss KH, Schaefer Y, Kloeters-Plachky P, Stiehl A, Stremmel W, Sauer P, Gotthardt DN. Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis. World J Gastroenterol 2013; 19(33): 5454-5463 |
URL |
http://www.wjgnet.com/1007-9327/full/v19/i33/5454.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v19.i33.5454 |
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