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Articles Published Processes
1/14/2017 10:42:00 AM | Browse: 905 | Download: 1342
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Received |
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2016-08-30 13:28 |
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Peer-Review Started |
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2016-08-31 09:20 |
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To Make the First Decision |
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2016-10-10 13:27 |
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Return for Revision |
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2016-10-13 17:24 |
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Revised |
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2016-11-09 04:11 |
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Second Decision |
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2016-12-09 17:42 |
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Accepted by Journal Editor-in-Chief |
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2016-12-11 18:05 |
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Accepted by Executive Editor-in-Chief |
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2016-12-19 17:18 |
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Articles in Press |
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2016-12-19 17:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-01-05 14:40 |
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Publish the Manuscript Online |
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2017-01-14 10:27 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Pancreatic stellate cell: Pandora's box for pancreatic disease biology
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ratnakar R Bynigeri, Aparna Jakkampudi, Ramaiah Jangala, Chivukula Subramanyam, Mitnala Sasikala, G Venkat Rao, D Nageshwar Reddy and Rupjyoti Talukdar |
| Funding Agency and Grant Number |
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| Corresponding Author |
Rupjyoti Talukdar, MD, Clinical Pancreatologist, Asian Institute of Gastroenterology, Clinician Scientist (Wellcome-DBT Fellow), Asian Healthcare Foundation, 6-3-661 Somajiguda, Hyderabad 500082, Telangana, India. rup_talukdar@yahoo.com |
| Key Words |
Pancreatic stellate cells; Pancreatic fibrosis; Pancreatic cancer stroma; Physiological functions; Pancreatic stellate cells-cancer-stromal interactions; Therapeutic targets |
| Core Tip |
Pancreatic stellate cells (PSCs) have emerged as one of the major effector cells in chronic pancreatitis and pancreatic ductal adenocarcinoma. In this review, we discuss the physiological function of PSCs and the profibrogenic mechanisms. We also discuss various pathways, transcription factors and miRNAs implicated in the inflammatory and profibrogenic functions mediated by PSCs. We further discuss the crosstalk among PSCs, pancreatic cancer cells and pancreatic cancer stroma and mechanisms that lead to cancer progression, metastasis, tumour hypoxia, immune evasion and drug resistance. We conclude with recent preclinical and clinical studies that have targeted PSCs and cancer stroma. |
| Publish Date |
2017-01-14 10:27 |
| Citation |
Bynigeri RR, Jakkampudi A, Jangala R, Subramanyam C, Sasikala M, Rao GV, Reddy DN, Talukdar R. Pancreatic stellate cell: Pandora's box for pancreatic disease biology. World J Gastroenterol 2017; 23(3): 382-405 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i3/382.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i3.382 |
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