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Articles Published Processes
2/12/2017 5:24:00 PM | Browse: 1175 | Download: 1853
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Received |
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2016-08-31 10:11 |
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Peer-Review Started |
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2016-08-31 19:08 |
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To Make the First Decision |
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2016-09-28 09:24 |
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Return for Revision |
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2016-09-28 15:06 |
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Revised |
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2016-10-11 15:37 |
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Second Decision |
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2016-10-18 20:26 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-10-27 17:25 |
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Articles in Press |
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2016-10-27 17:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-12-01 04:52 |
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Typeset the Manuscript |
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2017-02-04 14:27 |
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Publish the Manuscript Online |
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2017-02-12 17:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Jia Bu, Han-Qing Yu, Lu-Lu Fan, Xiao-Qiu Li, Fang Wang, Jia-Tao Liu, Fei Zhong, Cong-Jun Zhang, Wei Wei, Hua Wang and Guo-Ping Sun |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81572430 |
| National Natural Science Foundation of China |
81272739 |
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| Corresponding Author |
Dr. Guo-Ping Sun, Department of Oncology, the First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. sunguoping@ahmu.edu.cn |
| Key Words |
Melatonin; Endoplasmic reticulum stress; Activating transcription factor 6; Cyclooxygenase-2; Hepatocellular carcinoma |
| Core Tip |
Endoplasmic reticulum (ER) stress plays an important role in tumor growth and resistance to treatment. Our previous studies have already shown that melatonin sensitizes the human hepatocellular carcinoma cell to ER stress-induced apoptosis and attenuates ER stress-induced doxorubicin resistance. In this study, we first identified that melatonin selectively blocked ER stress downstream activating transcription factor 6 (ATF-6) and then inhibited cyclooxygenase-2 expression, leading to enhanced liver cancer cell apoptosis under ER stress condition. Our findings indicate that melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis. |
| Publish Date |
2017-02-12 17:23 |
| Citation |
Bu LJ, Yu HQ, Fan LL, Li XQ, Wang F, Liu JT, Zhong F, Zhang CJ, Wei W, Wang H, Sun GP. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol 2017; 23(6): 986-998 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i6/986.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i6.986 |
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