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Publication Name World Journal of Gastroenterology
Manuscript ID 29948
Country of Manuscript Source China
2016-08-31 10:11
Peer-Review Started
2016-08-31 19:08
To Make the First Decision
2016-09-28 09:24
Return for Revision
2016-09-28 15:06
2016-10-11 15:37
Second Decision
2016-10-18 20:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-10-27 17:25
Articles in Press
2016-10-27 17:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-12-01 04:52
Typeset the Manuscript
2017-02-04 14:27
Publish the Manuscript Online
2017-02-12 17:23
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Biochemistry and Molecular Biology
Manuscript Type Basic Study
Article Title Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation
Manuscript Source Unsolicited Manuscript
All Author List Li-Jia Bu, Han-Qing Yu, Lu-Lu Fan, Xiao-Qiu Li, Fang Wang, Jia-Tao Liu, Fei Zhong, Cong-Jun Zhang, Wei Wei, Hua Wang and Guo-Ping Sun
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81572430
National Natural Science Foundation of China 81272739
Correspondence To Dr. Guo-Ping Sun, Department of Oncology, the First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. sunguoping@ahmu.edu.cn
Keywords Melatonin; Endoplasmic reticulum stress; Activating transcription factor 6; Cyclooxygenase-2; Hepatocellular carcinoma
Core Tip Endoplasmic reticulum (ER) stress plays an important role in tumor growth and resistance to treatment. Our previous studies have already shown that melatonin sensitizes the human hepatocellular carcinoma cell to ER stress-induced apoptosis and attenuates ER stress-induced doxorubicin resistance. In this study, we first identified that melatonin selectively blocked ER stress downstream activating transcription factor 6 (ATF-6) and then inhibited cyclooxygenase-2 expression, leading to enhanced liver cancer cell apoptosis under ER stress condition. Our findings indicate that melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.
Publish Date 2017-02-12 17:23
Citation Bu LJ, Yu HQ, Fan LL, Li XQ, Wang F, Liu JT, Zhong F, Zhang CJ, Wei W, Wang H, Sun GP. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol 2017; 23(6): 986-998
Url http://www.wjgnet.com/1007-9327/full/v23/i6/986.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i6.986
Full Article (PDF) WJG-23-986.pdf
Full Article (Word) WJG-23-986.doc
Revised Manuscript 29948-Review.docx
Peer-review Report 29948-Peer-review(s).pdf
Answering Reviewers 29948-Answering reviewers.pdf
Scientific Misconduct Check 29948-Scientific misconduct check.pdf
Scientific Editor Work List 29948-Scientific editor work list.pdf
Audio Core Tip 29948-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 29948-Conflict-of-interest statement.pdf
Copyright License Agreement 29948-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 29948-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 29948-Language certificate.pdf
Scientific Research Process 29948-Scientific research process.pdf