Publication Name	World Journal of Respirology
Manuscript ID	29959
Country	United Kingdom

Received	2016-09-01 10:35
Peer-Review Started	2016-09-05 10:38
To Make the First Decision	2016-11-10 08:54
Return for Revision	2016-11-14 12:13
Revised	2016-11-23 20:14
Second Decision	2016-12-26 18:17
Accepted by Journal Editor-in-Chief	2016-12-29 09:59
Accepted by Executive Editor-in-Chief	2017-01-14 14:56
Articles in Press	2017-01-14 14:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-09 17:51
Publish the Manuscript Online	2017-03-28 19:29

ISSN	2218-6255 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Review
Article Title	Phenotyping emphysema and airways disease: Clinical value of quantitative radiological techniques
Manuscript Source	Invited Manuscript
All Author List	Diana Crossley, Alice Turner and Deepak Subramanian
Funding Agency and Grant Number
Corresponding Author	Diana Crossley, MbChB, MRCP, Clinical Research Fellow, Centre for Translational Inflammation Research, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham B15 2TH, United Kingdom. crossled@adf.bham.ac.uk
Key Words	Chronic obstructive pulmonary disease; Alpha one antitrypsin deficiency; Computed tomography; Densitometry; Phenotype; Spirometry; Magnetic reson­ance imaging
Core Tip	Phenotyping emphysematous patients radio-logically allow physicians to diagnose and deliver tai-lored and targeted therapies that are not possible with spirometry. When patients are divided into chronic bronchitis or emphysema on computed tomography (CT), they have significantly different clinical features and spirometry, demonstrating its ability to characterise phenotypic differences. CT offers accurate mapping and measurement of emphysema whereas magnetic resonance imaging (MRI) can provide functional informa-tion relating to ventilation and perfusion. This unique feature of MRI can help prognosticate patients in whom surgery is being considered. CT and MRI have both been sufficiently validated clinically and pathologically.
Publish Date	2017-03-28 19:29
Citation	Crossley D, Turner A, Subramanian D. Phenotyping emphysema and airways disease: Clinical value of quantitative radiological techniques. World J Respirol 2017; 7(1): 1-16
URL	http://www.wjgnet.com/2218-6255/full/v7/i1/1.htm
DOI	http://dx.doi.org/10.5320/wjr.v7.i1.1

Full Article (PDF)	WJR-7-1.pdf
Full Article (Word)	WJR-7-1.doc
Manuscript File	29959-Review.docx
Answering Reviewers	29959-Answering reviewers.pdf
Audio Core Tip	29959-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	29959-Conflict-of-interest statement.pdf
Copyright License Agreement	29959-Copyright assignment.pdf
Peer-review Report	29959-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	29959-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	29959-Scientific misconduct check.pdf
Scientific Editor Work List	29959-Scientific editor work list.pdf