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Articles Published Processes
2/15/2017 11:49:00 AM | Browse: 912 | Download: 1365
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Received |
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2016-09-02 12:55 |
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Peer-Review Started |
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2016-09-06 17:06 |
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To Make the First Decision |
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2016-09-26 08:58 |
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Return for Revision |
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2016-09-29 16:06 |
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Revised |
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2016-10-13 21:12 |
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Second Decision |
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2016-12-06 11:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2016-12-14 17:29 |
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Articles in Press |
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2016-12-14 17:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-02-12 21:56 |
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Publish the Manuscript Online |
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2017-02-15 11:49 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Maha Coucha, Islam N Mohamed, Sally L Elshaer, Osinakachuk Mbata, Megan L Bartasis and Azza B El-Remessy |
| Funding Agency and Grant Number |
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| Corresponding Author |
Azza El-Remessy, PhD, RPh, FAHA, Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, 114 Academic Building, Augusta, GA 30912, United States. aelremessy@augusta.edu
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| Key Words |
High fat diet; Palmitate; Endoplasmic-reticulum-stress; Inflammation; Thioredoxin-interacting protein; Micro-RNA 17-5p |
| Core Tip |
We previously showed that high fat diets (HFD) induced retinal inflammation and vascular dysfunction. These results were associated with an increase in thioredoxin interacting protein (TXNIP) at the mRNA and protein level. Here, we examined the mechanisms by which HFD triggers retinal TXNIP. Interestingly, we found that HFD/palmitate triggers ER-stress mediators including the inositol requiring enzyme 1, an RNAse that can degrade number of mRNAs including the microRNA; miR-17-5p and sustains TXNIP expression. Inhibiting ER-stress prevented the increase in TXNIP in vivo and in Müller cells, the main glia in the retina. Deletion of TXNIP blunted NLRP-3 inflammasome and IL-1β release in Müller cells.
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| Publish Date |
2017-02-15 11:49 |
| Citation |
Coucha M, Mohamed IN, Elshaer SL, Mbata O, Bartasis ML, El-Remessy AB. High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress. World J Diabetes 2017; 8(2): 56-65 |
| URL |
http://www.wjgnet.com/1948-9358/full/v8/i2/56.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v8.i2.56 |
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