BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
2/20/2017 5:58:00 PM | Browse: 1202 | Download: 1953
 |
Received |
|
2016-09-06 17:12 |
|
Peer-Review Started |
|
2016-09-08 20:15 |
|
To Make the First Decision |
|
2016-10-20 14:41 |
|
Return for Revision |
|
2016-10-24 20:22 |
|
Revised |
|
2016-11-09 14:10 |
|
Second Decision |
|
2016-12-14 17:40 |
 |
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2016-12-19 17:11 |
|
Articles in Press |
|
2016-12-19 17:11 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
2017-01-18 07:51 |
|
Typeset the Manuscript |
|
2017-02-07 17:15 |
|
Publish the Manuscript Online |
|
2017-02-20 17:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
|
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hsi-Hsien Hsu, Ming-Cheng Chen, Cecilia Hsuan Day, Yueh-Min Lin, Shin-Yi Li, Chuan-Chou Tu, Viswanadha Vijaya Padma, Hui-Nung Shih, Wei-Wen Kuo and Chih-Yang Huang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence |
MOHW105-TDU-B-212-133019 |
|
| Corresponding Author |
Chih-Yang Huang, PhD, Graduate Institute of Chinese Medical Science, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402,
Taiwan. cyhuang@mail.cmu.edu.tw
|
| Key Words |
Thymoquinone; LoVo cell; Cyclooxygenase 2; Prostaglandin E2; migration |
| Core Tip |
prostaglandin E2 (PGE2) induces migration of human LoVo colon cancer cells, and the major mechanism involves the activation of the p-Akt/p-PI3K/p-GSK3β/β-catenin/LEF-1/TCF-4 pathway that ultimately up-regulates cyclooxygenase 2 (COX-2) expression. Thymoquinone (TQ) suppresses cancer cell migration and represents a potential therapeutic target for colon adenocarcinoma metastasis. PGE2 activation of COX-2 and β-catenin to induce human LoVo colon cancer cell migration was blocked by TQ. Our study used cell proliferation assay, immunoblotting assay, immunofluorescence assay, nuclear extraction and in vivo experiments to examine the COX2 protein, which affects the metastasis of highly metastatic LoVo cancer cells treated with TQ.
|
| Publish Date |
2017-02-20 17:58 |
| Citation |
Hsu HH, Chen MC, Day CH, Lin YM, Li SY, Tu CC, Padma VV, Shih HN, Kuo WW, Huang CY. Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation. World J Gastroenterol 2017; 23(7): 1171-1179 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i7/1171.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i7.1171 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
