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2/20/2017 5:58:00 PM | Browse: 384 | Download: 513
Publication Name World Journal of Gastroenterology
Manuscript ID 30047
Country/Territory Taiwan
2016-09-06 17:12
Peer-Review Started
2016-09-08 20:15
To Make the First Decision
2016-10-20 14:41
Return for Revision
2016-10-24 20:22
2016-11-09 14:10
Second Decision
2016-12-14 17:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-12-19 17:11
Articles in Press
2016-12-19 17:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-01-18 07:51
Typeset the Manuscript
2017-02-07 17:15
Publish the Manuscript Online
2017-02-20 17:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation
Manuscript Source Unsolicited Manuscript
All Author List Hsi-Hsien Hsu, Ming-Cheng Chen, Cecilia Hsuan Day, Yueh-Min Lin, Shin-Yi Li, Chuan-Chou Tu, Viswanadha Vijaya Padma, Hui-Nung Shih, Wei-Wen Kuo and Chih-Yang Huang
Funding Agency and Grant Number
Funding Agency Grant Number
Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence MOHW105-TDU-B-212-133019
Corresponding author Chih-Yang Huang, PhD, Graduate Institute of Chinese Medical Science, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan. cyhuang@mail.cmu.edu.tw
Keywords Thymoquinone; LoVo cell; Cyclooxygenase 2; Prostaglandin E2; migration
Core Tip prostaglandin E2 (PGE2) induces migration of human LoVo colon cancer cells, and the major mechanism involves the activation of the p-Akt/p-PI3K/p-GSK3β/β-catenin/LEF-1/TCF-4 pathway that ultimately up-regulates cyclooxygenase 2 (COX-2) expression. Thymoquinone (TQ) suppresses cancer cell migration and represents a potential therapeutic target for colon adenocarcinoma metastasis. PGE2 activation of COX-2 and β-catenin to induce human LoVo colon cancer cell migration was blocked by TQ. Our study used cell proliferation assay, immunoblotting assay, immunofluorescence assay, nuclear extraction and in vivo experiments to examine the COX2 protein, which affects the metastasis of highly metastatic LoVo cancer cells treated with TQ.
Publish Date 2017-02-20 17:58
Citation Hsu HH, Chen MC, Day CH, Lin YM, Li SY, Tu CC, Padma VV, Shih HN, Kuo WW, Huang CY. Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation. World J Gastroenterol 2017; 23(7): 1171-1179
Url http://www.wjgnet.com/1007-9327/full/v23/i7/1171.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i7.1171
Full Article (PDF) WJG-23-1171.pdf
Full Article (Word) WJG-23-1171.doc
Manuscript File 30047-Review.docx
Answering Reviewers 30047-Answering reviewers.pdf
Audio Core Tip 30047-Audio core tip.MP3
Biostatistics Review Certificate 30047-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 30047-Conflict-of-interest statement.pdf
Copyright License Agreement 30047-Copyright assignment.pdf
Data Sharing Statement 30047-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 30047-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 30047-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 30047-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 30047-Language certificate.pdf
Scientific Research Process 30047-Scientific research process.pdf
Peer-review Report 30047-Peer-review(s).pdf
Scientific Misconduct Check 30047-Scientific misconduct check.pdf
Scientific Editor Work List 30047-Scientific editor work list.pdf