| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Prognostic value of glycated hemoglobin in colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Patrizia Ferroni, Vincenzo Formica, David Della-Morte, Jessica Lucchetti, Antonella Spila, Roberta D'Alessandro, Silvia Riondino, Fiorella Guadagni and Mario Roselli |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| European Social Fund, under the Italian Ministry of Education, University and Research |
PON03PE_00146_1/10 BIBIOFAR (CUP B88F12000730005) |
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| Corresponding Author |
Patrizia Ferroni, MD, PhD, San Raffaele Roma Open University, IRCCS San Raffaele Pisana, Via di Val Cannuta 247, 00166 Rome, Italy. patrizia.ferroni@sanraffaele.it |
| Key Words |
Colorectal cancer; Type 2 diabetes; Glycated hemoglobin; Insulin resistance; Prognostic value |
| Core Tip |
The clinical significance of routinely used pre-treatment fasting blood glucose, insulin, HbA1c and homeostasis model of risk assessment was investigated in a cohort of colorectal cancer (CRC) patients. Despite all four metabolic markers were elevated in non-diabetic CRC patients, only elevated HbA1c levels were significantly associated with advanced CRC stage and disease progression, showing a negative prognostic value both in terms of progression-free (HR = 1.24) and overall (HR = 1.36) survival after adjustment for major confounders. These results suggest that glycemic metabolic markers, mainly HbA1c, should be carefully monitored in CRC patients as they could provide important risk stratification information.
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| Publish Date |
2016-12-06 17:24 |
| Citation |
Ferroni P, Formica V, Della-Morte D, Lucchetti J, Spila A, D’Alessandro R, Riondino S, Guadagni F, Roselli M. Prognostic value of glycated hemoglobin in colorectal cancer. World J Gastroenterol 2016; 22(45): 9984-9993 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i45/9984.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i45.9984 |
