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Articles Published Processes
5/6/2017 8:30:21 PM | Browse: 1266 | Download: 2207
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Received |
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2016-09-12 08:49 |
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Peer-Review Started |
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2016-09-12 21:15 |
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To Make the First Decision |
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2016-10-20 14:41 |
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Return for Revision |
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2016-10-25 14:43 |
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Revised |
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2016-12-07 11:01 |
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Second Decision |
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2017-01-16 11:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-01-18 16:16 |
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Articles in Press |
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2017-01-18 16:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-03-24 17:03 |
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Typeset the Manuscript |
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2017-04-21 16:53 |
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Publish the Manuscript Online |
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2017-05-06 20:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Low-grade slightly elevated and polypoid colorectal adenomas display differential β-catenin-TCF/LEF activity, c-Myc, and cyclin D1 expression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tian-Wen Yang, Yun-Han Gao, Sha-Ying Ma, Qiang Wu and Zhong-Fu Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Yongchuan Chongqing Medical University Hospital Fund |
YJYB2012009 |
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| Corresponding Author |
Zhong-Fu Li, MD, Department of General Surgery, Chongqing Emergency Medical Center, No. 1, Jiankang Road, Yongchuan District, Chongqing 400014, China. li_zhongfu@sina.com |
| Key Words |
Cancer; Carcinoma; Colorectal; Adenoma; β-catenin; Non-polypoid |
| Core Tip |
We comparatively investigated the cellular and molecular characteristics of low-grade slightly elevated adenomas and low-grade polypoid adenomas. Slightly elevated lesions displayed a significantly lower apoptotic index as well as significantly upregulated β-catenin expression and β-catenin-TCF/LEF-driven transcriptional activity. Slightly elevated lesions also displayed c-Myc downregulation, cyclin D1 upregulation, upregulation of Bcl-2 and Bcl-xL, and downregulation of caspase-9 and caspase-3 activity. Low-grade slightly elevated adenomas displayed a lower apoptotic activity relative to low-grade polypoid adenomas, which can be partly attributed to upregulated β-catenin pathway activity and downregulated c-Myc expression. |
| Publish Date |
2017-05-06 20:30 |
| Citation |
Yang TW, Gao YH, Ma SY, Wu Q, Li ZF. Low-grade slightly elevated and polypoid colorectal adenomas display differential β-catenin-TCF/LEF activity, c-Myc, and cyclin D1 expression. World J Gastroenterol 2017; 23(17): 3066-3076 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i17/3066.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i17.3066 |
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