Publication Name	World Journal of Gastroenterology
Manuscript ID	30113
Country	China

Received	2016-09-12 08:47
Peer-Review Started	2016-09-12 17:25
To Make the First Decision	2016-10-20 13:00
Return for Revision	2016-10-21 10:55
Revised	2016-10-25 20:46
Second Decision	2016-11-11 14:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-11-16 16:35
Articles in Press	2016-11-16 16:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-28 11:49
Publish the Manuscript Online	2017-01-05 11:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier
Manuscript Source	Unsolicited Manuscript
All Author List	Da Zhou, Qin Pan, Feng-Zhi Xin, Rui-Nan Zhang, Chong-Xin He, Guang-Yu Chen, Chang Liu, Yuan-Wen Chen and Jian-Gao Fan
Funding Agency and Grant Number	Funding Agency Grant Number the State Key Development Program for Basic Research of China 2012CB517501 National Natural Science Foundation of China 81070322 National Natural Science Foundation of China 81270491 National Natural Science Foundation of China 81470840 National Natural Science Foundation of China 31400001
Corresponding Author	Dr. Jian-Gao Fan, Professor, Director, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. fattyliver2004@126.com
Key Words	Non-alcoholic fatty liver disease; Sodium butyrate; Gut microbiota; Gastrointestinal barrier; Endotoxin
Core Tip	Non-alcoholic fatty liver disease (NAFLD) is a global epidemic metabolic health crisis that lacks effective therapeutic strategies. We found that NaB could correct the high-fat diet (HFD)-induced gut microbiota imbalance in mice, while it considerably elevated the abundances of the beneficial bacteria. These bacteria can produce butyric acid in what seems like a virtuous circle. And butyrate restored HFD induced intestinal mucosa damage, improved tight junction structure, reduced gut endotoxin into liver, leading to attenuate HFD induced liver inflammation and lipid accumulation, which may be a potential gut microbiota modulator and therapeutic substance for NAFLD.
Publish Date	2017-01-05 11:10
Citation	Zhou D, Pan Q, Xin FZ, Zhang RN, He CX, Chen GY, Liu C, Chen YW, Fan JG. Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier. World J Gastroenterol 2017; 23(1): 60-75
URL	http://www.wjgnet.com/1007-9327/full/v23/i1/60.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i1.60

Full Article (PDF)	WJG-23-60.pdf
Full Article (Word)	WJG-23-60.doc
Manuscript File	30113-Review.doc
Answering Reviewers	30113-Answering reviewers.pdf
Audio Core Tip	30113-Audio core tip.mp3
Biostatistics Review Certificate	30113-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	30113-Conflict-of-interest statement.pdf
Copyright License Agreement	30113-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	30113-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160912001841.docx
Institutional Animal Care and Use Committee Approval Form or Document	30113-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	30113-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	30113-Language certificate.pdf
Supplementary Material	30113-Supplementary material.doc
Peer-review Report	30113-Peer-review(s).pdf
Scientific Misconduct Check	30113-Scientific misconduct check.pdf
Scientific Editor Work List	30113-Scientific editor work list.pdf