Publication Name	World Journal of Gastroenterology
Manuscript ID	3013
Country	Denmark

Received	2013-04-02 11:16
Peer-Review Started	2013-04-02 20:31
To Make the First Decision	2013-04-22 10:02
Return for Revision	2013-04-22 10:15
Revised	2013-05-03 21:40
Second Decision	2013-05-07 17:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-05-08 09:36
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-09 10:33
Publish the Manuscript Online	2013-05-14 16:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Field of Vision
Article Title	Relationships of CDXs and apical sodium-dependent bile acid transporter in Barrett's esophagus
Manuscript Source	Invited Manuscript
All Author List	Jingbo Zhao and Hans Gregersen
Funding Agency and Grant Number
Corresponding Author	Jingbo Zhao, MD, PhD, Mech-Sense, Department of Gastroenterology and Surgery, Aalborg University Hospital, Sdr. Skovvej 15, DK-9000 Aalborg, Denmark. jz@rn.dk
Key Words	Esophagus; Intestinal metaplasia; Caudal-related homeodomain transcription factors; Apical sodium-dependent bile acid transporter; Aberrant expression
Core Tip	Aberrant co-expression of Caudal-related homeodomain transcription factors (CDXs) and apical sodium-dependent bile acid transporter (ASBT) in the epithelium of Barrett's esophagus (BE) indicates association among these factors. Acid and bile re铿倁x induce CDXs gene expression and can lead to formation of BE. CDX-mediated promoter activation can lead to aberrant expression of ASBT. The BE phenotype may be better than squamous epithelium to protect against refluxed acid and bile. On the other hand the BE phenotype is associated with increased risk of esophageal adenocarcinoma (EAC). Furthermore, the decreased expressions of CDXs and ASBT in high-grade esophageal dysplasia indicate that CDXs and ASBT are inhibitory factors to the progression of EAC.
Publish Date	2013-05-14 16:05
Citation	Zhao J, Gregersen H. Relationships of CDXs and apical sodium-dependent bile acid transporter in Barrett’s esophagus. World J Gastroenterol 2013; 19(18): 2736-2739
URL	http://www.wjgnet.com/1007-9327/full/v19/i18/2736.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i18.2736

Full Article (PDF)	WJG-19-2736.pdf
Manuscript File	3013-Review.doc
Answering Reviewers	3013-Answering reviewers.pdf
Copyright License Agreement	3013-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3013-Language certificate.pdf
Peer-review Report	3013-Peer reviews.pdf
Scientific Editor Work List	3013-Scientific editor work list.doc