| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Association between endotoxemia and histological features of nonalcoholic fatty liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hiroyuki Kitabatake, Naoki Tanaka, Naoyuki Fujimori, Michiharu Komatsu, Ayaka Okubo, Kyogo Kakegawa, Takefumi Kimura, Ayumi Sugiura, Tomoo Yamazaki, Soichiro Shibata, Yuki Ichikawa, Satoru Joshita, Takeji Umemura, Akihiro Matsumoto, Masayoshi Koinuma, Kenji Sano, Toshifumi Aoyama and Eiji Tanaka |
| Funding Agency and Grant Number |
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| Corresponding Author |
Naoki Tanaka, MD, PhD, Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Asahi 3-1-1, Matsumoto 390-8621,
Japan. naopi@shinshu-u.ac.jp
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| Key Words |
nonalcoholic steatohepatitis; endotoxemia; lipopolysaccharide-binding protein; EndoCab IgG; fibrosis; steatosis |
| Core Tip |
This is the first study simultaneously measuring two surrogate endotoxemia markers, lipopolysaccharide-binding protein (LBP) and EndoCab IgG, in biopsy-proven nonalcoholic fatty liver disease (NAFLD) patients in order to assess for relationships with the histological features of NAFLD. Serum LBP/EndoCab IgG were not correlated with lobular inflammation or fibrosis. It remains elusive whether portal endotoxemia promotes hepatitis/fibrosis in human conventional NAFLD/nonalcoholic steatohepatitis.
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| Publish Date |
2017-01-19 11:16 |
| Citation |
Kitabatake H, Tanaka N, Fujimori N, Komatsu M, Okubo A, Kakegawa K, Kimura T, Sugiura A, Yamazaki T, Shibata S, Ichikawa Y, Joshita S, Umemura T, Matsumoto A, Koinuma M, Sano K, Aoyama T, Tanaka E. Association between endotoxemia and histological features of nonalcoholic fatty liver disease. World J Gastroenterol 2017; 23(4): 712-722 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i4/712.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i4.712 |
