Publication Name	World Journal of Hepatology
Manuscript ID	30144
Country	Greece

Received	2016-09-14 09:06
Peer-Review Started	2016-09-18 08:21
To Make the First Decision	2016-10-21 08:57
Return for Revision	2016-10-21 12:09
Revised	2016-11-20 01:06
Second Decision	2016-11-29 09:56
Accepted by Journal Editor-in-Chief	2016-11-29 17:09
Accepted by Executive Editor-in-Chief	2016-12-09 17:42
Articles in Press	2016-12-09 17:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-03 08:56
Publish the Manuscript Online	2017-02-06 09:08

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Interferon-free regimens in patients with hepatitis C infection and renal dysfunction or kidney transplantation
Manuscript Source	Invited Manuscript
All Author List	Evangelos Cholongitas, Chrysoula Pipili and George V Papatheodoridis
Funding Agency and Grant Number
Corresponding Author	Evangelos Cholongitas, Assistant Professor of Internal Medicine, 4<sup>th</sup> Department of Internal Medicine, Medical School of Aristotle University, Hippokration General Hospital of Thessaloniki, 49, Konstantinopoleos Street, 54642 Thessaloniki, Greece. cholongitas@yahoo.gr
Key Words	Chronic hepatitis C virus infection; Kidney; Renal; Kidney transplantation; Direct acting antiviral agents; Glomerular filtration rate; Hepatitis C
Core Tip	Recent evidence showed very good safety and efficacy of both interferon and ribavirin-free direct acting antivirals (DAAs) regimens in patients with severe kidney disease (CKD) or kidney transplantation. Nevertheless, sofosbuvir, the backbone of most antiviral schemes is officially contraindicated in patients with CKD (creatinine clearance < 30 mL/min). Accordingly, CKD patients with genotype 1 or 4 can be currently treated with available ribavirin free DAAs regimens without sofosbuvir, while those with non-1, non-4 genotype can officially be treated with peginterferon with or without ribavirin, but they are actually treated with sofosbuvir-based regimens mostly if they have advanced liver disease.
Publish Date	2017-02-06 09:08
Citation	Cholongitas E, Pipili C, Papatheodoridis GV. Interferon-free regimens in patients with hepatitis C infection and renal dysfunc­tion or kidney transplantation. World J Hepatol 2017; 9(4): 180-190
URL	http://www.wjgnet.com/1948-5182/full/v9/i4/180.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i4.180

Full Article (PDF)	WJH-9-180.pdf
Full Article (Word)	WJH-9-180.doc
Manuscript File	30144-Review.docx
Answering Reviewers	30144-Answering reviewers.pdf
Audio Core Tip	30144-Audio core tip.wma
Conflict-of-Interest Disclosure Form	30144-Conflict-of-interest statement.pdf
Copyright License Agreement	30144-Copyright assignment.pdf
Peer-review Report	30144-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	30144-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	30144-Scientific misconduct check.pdf
Scientific Editor Work List	30144-Scientific editor work list.pdf