Publication Name	World Journal of Orthopedics
Manuscript ID	30157
Country	Spain

Received	2016-09-15 09:25
Peer-Review Started	2016-09-19 09:06
To Make the First Decision	2016-10-21 09:00
Return for Revision	2016-10-21 12:18
Revised	2016-10-23 20:58
Second Decision	2016-11-10 14:43
Accepted by Journal Editor-in-Chief	2016-11-11 23:02
Accepted by Executive Editor-in-Chief	2016-11-22 15:11
Articles in Press	2016-11-22 15:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-09 15:07
Publish the Manuscript Online	2017-02-15 08:52

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Orthopedics
Manuscript Type	Editorial
Article Title	Challenges of bone tissue engineering in orthopaedic patients
Manuscript Source	Invited Manuscript
All Author List	Enrique Guerado and Enrique Caso
Funding Agency and Grant Number
Corresponding Author	Enrique Guerado, Professor and Chairman, Department of Orthopaedic Surgery and Traumatology, Hospital Costa del Sol, University of Malaga, Autovia A-7, Km 187, 29603 Marbella (Malaga), Spain. eguerado@hcs.es
Key Words	Bone loss; Mesenchymal stem cells; Reamer-irrigator-aspirator; Autograft; Personalised medicine; Bone transportation; Precision medicine; Masquelet technique
Core Tip	This paper discusses the problems created by large bone loss, especially after major trauma, and considers current alternatives to autograft or allograft, such as the reamer-irrigator-aspirator system, the Masquelet technique, bone transportation, or the combination of stem cell therapy and tissue engineering. Future Directions addressed mainly concern the new concepts of personalised medicine and precise medicine.
Publish Date	2017-02-15 08:52
Citation	Guerado E, Caso E. Challenges of bone tissue engineering in orthopaedic patients. World J Orthop 2017; 8(2): 87-98
URL	http://www.wjgnet.com/2218-5836/full/v8/i2/87.htm
DOI	http://dx.doi.org/10.5312/wjo.v8.i2.87

Full Article (PDF)	WJO-8-87.pdf
Full Article (Word)	WJO-8-87.doc
Manuscript File	30157-Review.doc
Answering Reviewers	30157-Answering reviewers.pdf
Audio Core Tip	30157-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	30157-Conflict-of-interest statement.pdf
Copyright License Agreement	30157-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	30157-Language certificate.pdf
Peer-review Report	30157-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	30157-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	30157-Scientific misconduct check.pdf
Scientific Editor Work List	30157-Scientific editor work list.pdf