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Articles Published Processes
6/7/2017 7:22:42 AM | Browse: 1164 | Download: 1570
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Received |
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2016-09-17 20:37 |
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Peer-Review Started |
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2016-09-18 09:05 |
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To Make the First Decision |
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2016-10-10 13:27 |
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Return for Revision |
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2016-10-13 17:27 |
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Revised |
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2016-10-27 22:27 |
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Second Decision |
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2016-11-11 14:40 |
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Accepted by Journal Editor-in-Chief |
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2016-11-11 23:31 |
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Accepted by Executive Editor-in-Chief |
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2016-12-08 15:45 |
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Articles in Press |
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2016-12-08 15:45 |
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Publication Fee Transferred |
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2017-04-17 17:44 |
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Edit the Manuscript by Language Editor |
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2017-05-11 19:22 |
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Typeset the Manuscript |
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2017-05-20 11:57 |
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Publish the Manuscript Online |
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2017-06-07 07:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Pleiotrophin and N-syndecan promote perineural invasion and tumor progression in an orthotopic mouse model of pancreatic cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun Yao, Lu-Lin Zhang, Xu-Mei Huang, Wen-Yao Li and She-Gan Gao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. U1204819 |
| Health Science and Technology Innovation Talents Program of Henan Province |
No. 4203 |
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| Corresponding Author |
Dr. She-Gan Gao, Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, the First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, 24 Jinghua Road, Jianxi District, Luoyang 471003, Henan Province, China. hospitalluo@163.com |
| Key Words |
Pleiotrophin; N-syndecan; Pancreatic cancer; Perineural invasion |
| Core Tip |
Perineural invasion (PNI) is a primary cause of local recurrence and poor survival in patients with pancreatic cancer. However, the exact mechanism of PNI remains unclear. Pleiotrophin (PTN) and its receptor, N-syndecan, may play an important role in tumor growth and PNI of pancreatic cancer. In a previous study, we found that high expression of PTN and N-syndecan may contribute to increased PNI and poor prognosis in patients with pancreatic cancer. In this study, we further elucidated the function of PTN and N-syndecan using an orthotopic mouse model of pancreatic cancer. We demonstrated that PTN and N-syndecan promoted tumor progression and PNI. |
| Publish Date |
2017-06-07 07:22 |
| Citation |
Yao J, Zhang LL, Huang XM, Li WY, Gao SG. Pleiotrophin and N-syndecan promote perineural invasion and tumor progression in an orthotopic mouse model of pancreatic cancer. World J Gastroenterol 2017; 23(21): 3907-3914 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i21/3907.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i21.3907 |
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