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Articles Published Processes
3/13/2017 7:05:00 PM | Browse: 1030 | Download: 1727
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Received |
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2016-09-18 13:31 |
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Peer-Review Started |
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2016-09-19 20:58 |
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To Make the First Decision |
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2016-10-20 13:00 |
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Return for Revision |
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2016-10-21 10:57 |
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Revised |
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2016-11-06 16:09 |
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Second Decision |
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2016-11-22 19:59 |
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Accepted by Journal Editor-in-Chief |
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2016-11-22 20:08 |
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Accepted by Company Editor-in-Chief |
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2016-12-02 11:57 |
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Articles in Press |
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2016-12-02 11:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-01-09 21:35 |
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Typeset the Manuscript |
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2017-01-20 10:11 |
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Publish the Manuscript Online |
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2017-03-13 19:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Clinicopathological significance of overexpression of interleukin-6 in colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun Zeng, Zhong-Hua Tang, Shuang Liu and Shan-Shan Guo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chinese National Natural Science Foundation of China |
81502131 |
| Natural Science Foundation Project of CQ |
cstc2016jcyjA0405 |
| the Scientific and Technological Research Program of Chongqing Municipal Education Commission |
KJ1500332 |
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| Corresponding Author |
Jun Zeng, PhD, College of Life Sciences, Chongqing Normal University, 37 Daxuecheng Middle Road, Chongqing 401331, China. zengjun_2012@163.com
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| Key Words |
Colorectal cancer; Interleukin-6; Invasion depth; Lymph node metastases |
| Core Tip |
Colorectal cancer (CRC) is the fourth leading cause of cancer-related death worldwide. Previous studies have demonstrated that interleukin (IL)-6 is a critical tumor promoter during early CRC tumorigenesis. However, there have been few studies regarding the expression of IL-6 and its prognostic role in CRC. Therefore, we explored the correlation between the expression of IL-6 and the clinicopathological features in CRC. To the best of our knowledge, this is the first analysis of the expression of IL-6 in resected CRC samples using immunohistochemistry combined with biostatistics. The results showed that the expression of IL-6 was correlated with tumour TNM stage and histological differentiation. Furthermore, IL-6 in tumour cells showed stronger immunoreactivity as tumour cells invaded deeply. These data indicated that IL-6 might be used as a potential therapeutic target in patients with CRC.
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| Publish Date |
2017-03-13 19:06 |
| Citation |
Zeng J, Tang ZH, Liu S, Guo SS. Clinicopathological significance of overexpression of interleukin-6 in colorectal cancer. World J Gastroenterol 2017; 23(10): 1780-1786 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i10/1780.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i10.1780 |
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