| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Clinical features of acute hepatitis E super-infections on chronic hepatitis B
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chong Chen, Shu-Ye Zhang, Dan-Dan Zhang, Xin-Yan Li, Yu-Ling Zhang, Wei-Xia Li, Jing-Jing Yan, Min Wang, Jing-Na Xun, Chuan Lu, Yun Ling, Yu-Xian Huang and Liang Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Project of Chinese National Programs for Fundamental Research and Development (973 program) |
2015CB554300 (to Zhang SY) |
| Joint Research Program for Emerging Frontier Technology in the Municipal Hospital of Shanghai, China |
SHDC12015129 |
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| Corresponding Author |
Liang Chen, Professor, Wenzhou Medical University, Ouhai District, Wenzhou 325000, Zhejiang Province, China. chenliang@shaphc.org
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| Key Words |
Cirrhosis; Co-infections; Liver failure; Liver decompensation; Stages of hepatitis B virus infection |
| Core Tip |
To determine whether status of chronic hepatitis B (CHB) affects clinical outcomes of hepatitis E virus (HEV) super-infections, we investigated immunological phases, hepatitis B virus (HBV) serum markers, HBV viral load and anti-viral treatments among 228 patients with HBV-HEV co-infection. Well-compensated patients were majorly affected by HEV super-infections, and hepatitis B e antigen-negative CHB patients had the worst clinical outcomes among non-cirrhotics. Lack of proper anti-HBV treatment may contribute to the worse outcomes. These data may help to facilitate development of vaccination programs that precisely target populations at risk of poor outcome from HBV-HEV co-infections.
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| Publish Date |
2016-12-19 20:29 |
| Citation |
Chen C, Zhang SY, Zhang DD, Li XY, Zhang YL, Li WX, Yan JJ, Wang M, Xun JN, Lu C, Ling Y, Huang YX, Chen L. Clinical features of acute hepatitis E super-infections on chronic hepatitis B. World J Gastroenterol 2016; 22(47): 10388-10397 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i47/10388.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i47.10388 |
