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2/26/2017 6:20:00 PM | Browse: 832 | Download: 1246
Publication Name World Journal of Gastroenterology
Manuscript ID 30234
Country/Territory China
Received
2016-09-21 09:11
Peer-Review Started
2016-09-21 10:13
To Make the First Decision
2016-10-20 14:00
Return for Revision
2016-10-21 10:52
Revised
2016-11-21 00:00
Second Decision
2016-12-01 12:13
Accepted by Journal Editor-in-Chief
2016-12-01 12:46
Accepted by Company Editor-in-Chief
2016-12-08 15:45
Articles in Press
2016-12-08 15:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-01-14 16:37
Typeset the Manuscript
2017-02-09 16:03
Publish the Manuscript Online
2017-02-26 18:20
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6
Manuscript Source Unsolicited Manuscript
All Author List Jun-Hui Guo, Guo-Lan Xing, Xin-Hui Fang, Hui-Fang Wu, Bo Zhang, Jin-Zhong Yu, Zong-Min Fan and Li-Dong Wang
Funding Agency and Grant Number
Corresponding Author Dr. Li-Dong Wang, Professor, Henan Key Lab For Esophageal Cancer Res, The First Affiliated Hospital of Zhengzhou University, No. 40 Daxue Road, Zhengzhou 450052, Henan Province, China. ldwang2007@126.com
Key Words Fetal esophageal epithelium; Esophageal squamous cell carcinoma; Tumor-adjacent esophageal epithelium; Proteomics
Core Tip This was a retrospective study to identify 21 significantly differentially expressed proteins that may be related to the development and growth of fetal esophageal epithelium or the development and progression of esophageal cancer. Peroxiredoxin (PRX)6 protein was localized mainly in the cytoplasm, and detected in adult and fetal normal esophageal tissues, precancerous lesions, and esophageal cancer. With the progression of esophageal lesions, PRX6 protein expression showed a declining trend. In epithelium from fetuses at gestational age 3-6 mo, PRX6 ex-pression showed a declining trend with age. PRX6 protein expression was significantly higher in well-differentiated than poorly differentiated esophageal cancer tissues. PRX6 protein is associated with fetal esophageal development and esophageal cancer differentiation.
Publish Date 2017-02-26 18:20
Citation Guo JH, Xing GL, Fang XH, Wu HF, Zhang B, Yu JZ, Fan ZM, Wang LD. Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6. World J Gastroenterol 2017; 23(8): 1434-1442
URL http://www.wjgnet.com/1007-9327/full/v23/i8/1434.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i8.1434
Full Article (PDF) WJG-23-1434.pdf
Full Article (Word) WJG-23-1434.doc
Manuscript File 30234-Review.docx
Answering Reviewers 30234-Answering reviewers.pdf
Audio Core Tip 30234-Audio core tip.m4a
Biostatistics Review Certificate 30234-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 30234-Conflict of interest statement.pdf
Copyright License Agreement 30234-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160920191700.pdf
Institutional Review Board Approval Form or Document 30234-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 30234-Language certificate.pdf
Peer-review Report 30234-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 30234-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 30234-Scientific misconduct check.pdf
Scientific Editor Work List 30234-Scientific editor work list.pdf