Publication Name	World Journal of Gastroenterology
Manuscript ID	30234
Country	China

Received	2016-09-21 09:11
Peer-Review Started	2016-09-21 10:13
To Make the First Decision	2016-10-20 14:00
Return for Revision	2016-10-21 10:52
Revised	2016-11-21 00:00
Second Decision	2016-12-01 12:13
Accepted by Journal Editor-in-Chief	2016-12-01 12:46
Accepted by Executive Editor-in-Chief	2016-12-08 15:45
Articles in Press	2016-12-08 15:45
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-01-14 16:37
Typeset the Manuscript	2017-02-09 16:03
Publish the Manuscript Online	2017-02-26 18:20

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6
Manuscript Source	Unsolicited Manuscript
All Author List	Jun-Hui Guo, Guo-Lan Xing, Xin-Hui Fang, Hui-Fang Wu, Bo Zhang, Jin-Zhong Yu, Zong-Min Fan and Li-Dong Wang
Funding Agency and Grant Number
Corresponding Author	Dr. Li-Dong Wang, Professor, Henan Key Lab For Esophageal Cancer Res, The First Affiliated Hospital of Zhengzhou University, No. 40 Daxue Road, Zhengzhou 450052, Henan Province, China. ldwang2007@126.com
Key Words	Fetal esophageal epithelium; Esophageal squamous cell carcinoma; Tumor-adjacent esophageal epithelium; Proteomics
Core Tip	This was a retrospective study to identify 21 significantly differentially expressed proteins that may be related to the development and growth of fetal esophageal epithelium or the development and progression of esophageal cancer. Peroxiredoxin (PRX)6 protein was localized mainly in the cytoplasm, and detected in adult and fetal normal esophageal tissues, precancerous lesions, and esophageal cancer. With the progression of esophageal lesions, PRX6 protein expression showed a declining trend. In epithelium from fetuses at gestational age 3-6 mo, PRX6 ex-pression showed a declining trend with age. PRX6 protein expression was significantly higher in well-differentiated than poorly differentiated esophageal cancer tissues. PRX6 protein is associated with fetal esophageal development and esophageal cancer differentiation.
Publish Date	2017-02-26 18:20
Citation	Guo JH, Xing GL, Fang XH, Wu HF, Zhang B, Yu JZ, Fan ZM, Wang LD. Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6. World J Gastroenterol 2017; 23(8): 1434-1442
URL	http://www.wjgnet.com/1007-9327/full/v23/i8/1434.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i8.1434

Full Article (PDF)	WJG-23-1434.pdf
Full Article (Word)	WJG-23-1434.doc
Manuscript File	30234-Review.docx
Answering Reviewers	30234-Answering reviewers.pdf
Audio Core Tip	30234-Audio core tip.m4a
Biostatistics Review Certificate	30234-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	30234-Conflict of interest statement.pdf
Copyright License Agreement	30234-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160920191700.pdf
Institutional Review Board Approval Form or Document	30234-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	30234-Language certificate.pdf
Peer-review Report	30234-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	30234-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	30234-Scientific misconduct check.pdf
Scientific Editor Work List	30234-Scientific editor work list.pdf