Publication Name	World Journal of Gastroenterology
Manuscript ID	30250
Country	Belgium

Received	2016-09-22 09:23
Peer-Review Started	2016-09-22 20:48
To Make the First Decision	2016-10-20 13:00
Return for Revision	2016-10-27 08:57
Revised	2016-11-10 18:10
Second Decision	2016-11-22 20:01
Accepted by Journal Editor-in-Chief	2016-11-22 20:07
Accepted by Executive Editor-in-Chief	2016-12-02 12:02
Articles in Press	2016-12-02 12:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-12 09:30
Publish the Manuscript Online	2016-12-19 20:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases
Manuscript Source	Invited Manuscript
All Author List	Hannah Ceuleers, Hanne Van Spaendonk, Nikita Hanning, Jelena Heirbaut, Anne-Marie Lambeir, Jurgen Joossens, Koen Augustyns, Joris G De Man, Ingrid De Meester and Benedicte Y De Winter
Funding Agency and Grant Number	Funding Agency Grant Number University Research Fund Doctoral Projects (BOF-DOCPRO) DOCPRO4 2014/ID 2964 Research Foundation Flanders (FWO) G034113N
Corresponding Author	Benedicte Y De Winter, Professor, MD, PhD, Laboratory of Experimental Medicine and Pediatrics, Division of Gastroenterology, University of Antwerp, Universi­teitsplein 1, 2610 Antwerpen, Belgium. benedicte.dewinter@uantwerpen.be
Key Words	Proteases; Proteinase-activated receptors; Protease inhibitors; Visceral hypersensitivity; Visceral pain; Irritable bowel syndrome; Inflammatory bowel diseases
Core Tip	Proteases are enzymes catalyzing the hy-drolysis of peptide bonds. They are present at high levels in the gastrointestinal tract and they execute a large variety of physiological and pathophysiological functions. In the last decade, it became clear that proteases fulfill an important role in visceral pain, a major symptom in patients with inflammatory bowel diseases and/or irritable bowel syndrome. These review articles aim at providing an overview of the diverse roles of proteases in both health and disease states related to the gastrointestinal functions, with the emphasis on visceral pain in this review.
Publish Date	2016-12-19 20:29
Citation	Ceuleers H, Van Spaendonk H, Hanning N, Heirbaut J, Lambeir AM, Joossens J, Augustyns K, De Man JG, De Meester I, De Winter BY. Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases. World J Gastroenterol 2016; 22(47): 10275-10286
URL	http://www.wjgnet.com/1007-9327/full/v22/i47/10275.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i47.10275

Full Article (PDF)	WJG-22-10275.pdf
Full Article (Word)	WJG-22-10275.doc
Manuscript File	30250-Review.docx
Answering Reviewers	30250-Answering reviewers.pdf
Audio Core Tip	30250-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	30250-Conflict-of-interest statement.pdf
Copyright License Agreement	30250-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	30250-Language certificate.pdf
Peer-review Report	30250-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	30250-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	30250-Scientific misconduct check.pdf
Scientific Editor Work List	30250-Scientific editor work list.pdf