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4/13/2017 7:14:44 PM | Browse: 491 | Download: 446
Publication Name World Journal of Diabetes
Manuscript ID 30269
Country of Manuscript Source France
Received
2016-09-23 09:05
Peer-Review Started
2016-09-23 17:46
To Make the First Decision
2016-10-20 08:47
Return for Revision
2016-11-02 16:02
Revised
2016-11-14 18:54
Second Decision
2017-01-04 16:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-01-18 10:22
Articles in Press
2017-01-18 10:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-04-12 15:13
Publish the Manuscript Online
2017-04-13 19:14
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology and Metabolism
Manuscript Type Basic Study
Article Title Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells
Manuscript Source Invited Manuscript
All Author List Christian Carpéné, Silvia Garcia-Vicente, Marta Serrano, Luc Marti, Chloé Belles, Miriam Royo, Jean Galitzky, Antonio Zorzano and Xavier Testar
Funding Agency and Grant Number
Funding Agency Grant Number
Institut National de la Santé et de la Recherche Médicale to the INSERM U1048
Corresponding author Dr. Christian Carpéné, Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, INSERM U1048, Institut. National de la Santé et de la Recherche Médicale & Université Paul Sabatier, CHU Rangueil, Cedex 4, 31432 Toulouse, France. christian.carpene@inserm.fr
Keywords Adipocyte; Lipolysis; Amine oxidases; Insulin resistance; Obesity; Hydrogen peroxide; Vanadium; Antidiabetics
Core Tip This study investigates in murine and human adipocytes the antilipolytic properties of a conjugate of benzylamine and decavanadate (B6V10), already reported to lower hyperglycaemia in diabetic rodents. Data indicated that the conjugate dose-dependently inhibited submaximal activation of lipolysis in all the species studied. Such antilipolytic action deals with the in vivo FFA-lowering properties already described for B6V10 in diabetic rats. B6V10 also activated lipogenesis and glucose transport in fat cells. B6V10 should therefore be useful in preventing the lipotoxicity constituted by the unrestrained lipolytic activity of insulin-resistant adipocytes in obese individuals presenting type 2 diabetes, a state named diabesity.
Publish Date 2017-04-13 19:14
Citation Carpéné C, Garcia-Vicente S, Serrano M, Marti L, Belles C, Royo M, Galitzky J, Zorzano A, Testar X. Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells. World J Diabetes 2017; 8(4): 143-153
Url http://www.wjgnet.com/1948-9358/full/v8/i4/143.htm
DOI http://dx.doi.org/10.4239/wjd.v8.i4.143
Full Article (PDF) WJD-8-143.pdf
Full Article (Word) WJD-8-143.doc
Manuscript File 30269-Review.docx
Answering Reviewers 30269-Answering reviewers.pdf
Audio Core Tip 30269-Audio core tip.m4a
Biostatistics Review Certificate 30269-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 30269-Conflict-of-interest statement.pdf
Copyright License Agreement 30269-Copyright assignment.pdf
Data Sharing Statement 30269-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 30269-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 30269-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 30269-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 30269-Language certificate.pdf
Scientific Research Process 30269-Scientific research process.pdf
Peer-review Report 30269-Peer-review(s).pdf
Scientific Misconduct Check 30269-Scientific misconduct check.pdf
Scientific Editor Work List 30269-Scientific editor work list.pdf