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Articles Published Processes
4/13/2017 7:14:44 PM | Browse: 1453 | Download: 2483
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Received |
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2016-09-23 09:05 |
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Peer-Review Started |
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2016-09-23 17:46 |
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To Make the First Decision |
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2016-10-20 08:47 |
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Return for Revision |
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2016-11-02 16:02 |
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Revised |
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2016-11-14 18:54 |
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Second Decision |
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2017-01-04 16:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-01-18 10:22 |
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Articles in Press |
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2017-01-18 10:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-04-12 15:13 |
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Publish the Manuscript Online |
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2017-04-13 19:14 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Christian Carpéné, Silvia Garcia-Vicente, Marta Serrano, Luc Marti, Chloé Belles, Miriam Royo, Jean Galitzky, Antonio Zorzano and Xavier Testar |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Institut National de la Santé et de la Recherche Médicale to the INSERM U1048 |
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| Corresponding Author |
Dr. Christian Carpéné, Institut des Maladies Métaboliques et Cardiovasculaires, I2MC, INSERM U1048, Institut. National de la Santé et de la Recherche Médicale & Université Paul Sabatier, CHU Rangueil, Cedex 4, 31432 Toulouse, France. christian.carpene@inserm.fr |
| Key Words |
Adipocyte; Lipolysis; Amine oxidases; Insulin resistance; Obesity; Hydrogen peroxide; Vanadium; Antidiabetics |
| Core Tip |
This study investigates in murine and human adipocytes the antilipolytic properties of a conjugate of benzylamine and decavanadate (B6V10), already reported to lower hyperglycaemia in diabetic rodents. Data indicated that the conjugate dose-dependently inhibited submaximal activation of lipolysis in all the species studied. Such antilipolytic action deals with the in vivo FFA-lowering properties already described for B6V10 in diabetic rats. B6V10 also activated lipogenesis and glucose transport in fat cells. B6V10 should therefore be useful in preventing the lipotoxicity constituted by the unrestrained lipolytic activity of insulin-resistant adipocytes in obese individuals presenting type 2 diabetes, a state named diabesity. |
| Publish Date |
2017-04-13 19:14 |
| Citation |
Carpéné C, Garcia-Vicente S, Serrano M, Marti L, Belles C, Royo M, Galitzky J, Zorzano A, Testar X. Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells. World J Diabetes 2017; 8(4): 143-153 |
| URL |
http://www.wjgnet.com/1948-9358/full/v8/i4/143.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v8.i4.143 |
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