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2/20/2017 5:58:00 PM | Browse: 1039 | Download: 1202
Publication Name World Journal of Gastroenterology
Manuscript ID 30284
Country/Territory Iran
Received
2016-09-24 14:23
Peer-Review Started
2016-09-25 21:18
To Make the First Decision
2016-10-20 13:00
Return for Revision
2016-10-27 08:57
Revised
2016-11-11 01:40
Second Decision
2016-12-29 10:48
Accepted by Journal Editor-in-Chief
2016-12-29 12:37
Accepted by Company Editor-in-Chief
2017-01-04 16:27
Articles in Press
2017-01-04 16:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-01-13 05:13
Typeset the Manuscript
2017-02-06 14:14
Publish the Manuscript Online
2017-02-20 17:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Microbiology
Manuscript Type Basic Study
Article Title Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics
Manuscript Source Invited Manuscript
All Author List Bahareh Attaran, Tahereh Falsafi and Nassim Ghorbanmehr
Funding Agency and Grant Number
Corresponding Author Dr. Tahereh Falsafi, Professor, Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Vanak Village Street, Tehran 1993893973, Iran. falsafi.tahereh@yahoo.com
Key Words Helicobacter pylori; Biofilm; Antibiotic resistance; Efflux genes; hp1165; hefA
Core Tip The current study has addressed the co-incidence of biofilm formation by Helicobacter pylori (H. pylori) and decreased susceptibility to antibiotics. The results demonstrated a significantly higher expression of two efflux pump genes, hp1165 and hefA (involved in the specific resistance to tetracycline and multidrug resistance, respectively), in the biofilm-forming cells as compared to the planktonic cells. There was also association between H. pylori biofilm formation and decreased susceptibility to antibiotics. This event would probably be involved in the failure of H. pylori eradication and might be beneficial for developing new therapeutic approaches for this infection.
Publish Date 2017-02-20 17:58
Citation Attaran B, Falsafi T, Ghorbanmehr N. Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics. World J Gastroenterol 2017; 23(7): 1163-1170
URL http://www.wjgnet.com/1007-9327/full/v23/i7/1163.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i7.1163
Full Article (PDF) WJG-23-1163.pdf
Full Article (Word) WJG-23-1163.doc
Manuscript File 30284-Review.doc
Answering Reviewers 30284-Answering reviewers.pdf
Audio Core Tip 30284-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 30284-Conflict-of-interest statement.pdf
Copyright License Agreement 30284-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 30284-Institutional review board statement.pdf
Peer-review Report 30284-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 30284-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 30284-Scientific misconduct check.pdf
Scientific Editor Work List 30284-Scientific editor work list.pdf