Publication Name	World Journal of Gastroenterology
Manuscript ID	30284
Country	Iran

Received	2016-09-24 14:23
Peer-Review Started	2016-09-25 21:18
To Make the First Decision	2016-10-20 13:00
Return for Revision	2016-10-27 08:57
Revised	2016-11-11 01:40
Second Decision	2016-12-29 10:48
Accepted by Journal Editor-in-Chief	2016-12-29 12:37
Accepted by Executive Editor-in-Chief	2017-01-04 16:27
Articles in Press	2017-01-04 16:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-01-13 05:13
Typeset the Manuscript	2017-02-06 14:14
Publish the Manuscript Online	2017-02-20 17:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Microbiology
Manuscript Type	Basic Study
Article Title	Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics
Manuscript Source	Invited Manuscript
All Author List	Bahareh Attaran, Tahereh Falsafi and Nassim Ghorbanmehr
Funding Agency and Grant Number
Corresponding Author	Dr. Tahereh Falsafi, Professor, Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Vanak Village Street, Tehran 1993893973, Iran. falsafi.tahereh@yahoo.com
Key Words	Helicobacter pylori; Biofilm; Antibiotic resistance; Efflux genes; hp1165; hefA
Core Tip	The current study has addressed the co-incidence of biofilm formation by Helicobacter pylori (H. pylori) and decreased susceptibility to antibiotics. The results demonstrated a significantly higher expression of two efflux pump genes, hp1165 and hefA (involved in the specific resistance to tetracycline and multidrug resistance, respectively), in the biofilm-forming cells as compared to the planktonic cells. There was also association between H. pylori biofilm formation and decreased susceptibility to antibiotics. This event would probably be involved in the failure of H. pylori eradication and might be beneficial for developing new therapeutic approaches for this infection.
Publish Date	2017-02-20 17:58
Citation	Attaran B, Falsafi T, Ghorbanmehr N. Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics. World J Gastroenterol 2017; 23(7): 1163-1170
URL	http://www.wjgnet.com/1007-9327/full/v23/i7/1163.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i7.1163

Full Article (PDF)	WJG-23-1163.pdf
Full Article (Word)	WJG-23-1163.doc
Manuscript File	30284-Review.doc
Answering Reviewers	30284-Answering reviewers.pdf
Audio Core Tip	30284-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	30284-Conflict-of-interest statement.pdf
Copyright License Agreement	30284-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	30284-Institutional review board statement.pdf
Peer-review Report	30284-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	30284-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	30284-Scientific misconduct check.pdf
Scientific Editor Work List	30284-Scientific editor work list.pdf