| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Remote ischemic perconditioning prevents liver transplantation-induced ischemia/reperfusion injury in rats: Role of ROS/RNS and eNOS
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ning He, Jun-Jun Jia, Jian-Hui Li, Yan-Fei Zhou, Bing-Yi Lin, Yi-Fan Peng, Jun-Jie Chen, Tian-Chi Chen, Rong-Liang Tong, Li Jiang, Hai-Yang Xie, Lin Zhou and Shu-Sen Zheng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81421062 |
| Science and Technology Bureau of Zhejiang Province, China |
2016C33145 |
| National Natural Science Foundation of China |
81470891 |
| The 863 National High Technology Research and Development Program of China for Young Scientist |
2015AA020923 |
|
| Corresponding Author |
Shu-Sen Zheng, MD, PhD, FACS, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. shusenzheng@zju.edu.cn |
| Key Words |
Liver transplantation; Ischemia/reperfusion injury; Remote ischemic perconditioning; Endothelial nitric oxide synthase; Reactive oxygen species |
| Core Tip |
This study is believed to be the first to investigate remote ischemic conditioning using a novel model of remote ischemic perconditioning (RIPerC) in liver transplantation and to identify the PI3K/Akt/endothelial nitric oxide (NO) synthase/NO axis involved. Compared to the traditional method of ischemic postconditioning, RIPerC works similar to or better than it and overcomes the main concern of increasing total ischemic time, which may lead to problems. RIPerC appears as the most promising technique to avoid ischemia/reperfusion injury in liver transplantation and is convenient clinically. |
| Publish Date |
2017-01-22 11:39 |
| Citation |
He N, Jia JJ, Li JH, Zhou YF, Lin BY, Peng YF, Chen JJ, Chen TC, Tong RL, Jiang L, Xie HY, Zhou L, Zheng SS. Remote ischemic perconditioning prevents liver transplantation-induced ischemia/reperfusion injury in rats: Role of ROS/RNS and eNOS. World J Gastroenterol 2017; 23(5): 830-841 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i5/830.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i5.830 |
