Publication Name	World Journal of Gastroenterology
Manuscript ID	3031
Country	Japan

Received	2013-04-04 19:25
Peer-Review Started	2013-04-04 23:40
First Decision by Editorial Office Director
Return for Revision	2013-05-20 10:48
Revised	2013-06-12 19:03
Publication Fee Transferred
Second Decision by Editor	2013-07-05 10:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-07-05 12:48
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-06 13:54
Publish the Manuscript Online	2013-08-24 14:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Human platelets inhibit liver fibrosis in severe combined immunodeficiency mice
Manuscript Source	Invited Manuscript
All Author List	Kazuhiro Takahashi, Soichiro Murata, Kiyoshi Fukunaga and Nobuhiro Ohkohchi
Funding Agency and Grant Number	Funding Agency Grant Number University of Tsukuba, the Basic Research Support Program for Young Researcher
Corresponding Author	Dr. Nobuhiro Ohkohchi, MD, PhD, Department of Surgery, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 3058575, Japan. nokochi3@md.tsukuba.ac.jp
Key Words	Human platelet; Liver fibrosis; Hepatocyte apoptosis; Hepatocyte growth factor; Transforming growth factor-β; Matrix metallopeptidases
Core Tip	We assessed the effects of human platelet transfusion on liver fibrosis. Severe combined immunodeficiency (SCID) mice were administered CCl4 and either phosphate-buffered saline or human platelets. The effects of a human platelet transfusion on liver fibrosis and hepatocyte apoptosis were compared. The fibrotic area, hydroxyproline content, and α-smooth muscle actin expression were decreased in mice that received human platelet transfusions. Transfusion increased mouse hepatocyte growth factor (HGF) and matrix metallopeptidases (MMP)-9 levels in the liver and decreased mouse transforming growth factor-β. Furthermore, transfusion suppressed hepatocyte apoptosis. Human platelets inhibited liver fibrosis in SCID mice. Increased concentration of HGF in the liver suppresses hepatic stellate cell activation, induces MMPs, and inhibits hepatocyte apoptosis.
Publish Date	2013-08-24 14:11
Citation	Takahashi K, Murata S, Fukunaga K, Ohkohchi N. Human platelets inhibit liver fibrosis in severe combined immunodeficiency mice. World J Gastroenterol 2013; 19(32): 5250-5260
URL	http://www.wjgnet.com/1007-9327/full/v19/i32/5250.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i32.5250

Full Article (PDF)	WJG-19-5250.pdf
Manuscript File	3031-Review.doc
Answering Reviewers	3031-Answering reviewers.pdf
Copyright License Agreement	3031-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3031-Language certificate.pdf
Peer-review Report	3031-Peer reviews.pdf
Scientific Editor Work List	3031-Scientific editor work list.doc