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1/5/2017 11:10:00 AM | Browse: 563 | Download: 771
Publication Name World Journal of Gastroenterology
Manuscript ID 30371
Country/Territory Canada
Received
2016-09-30 10:31
Peer-Review Started
2016-09-30 17:45
To Make the First Decision
2016-12-02 08:19
Return for Revision
2016-12-02 10:50
Revised
2016-12-09 05:23
Second Decision
2016-12-16 17:20
Accepted by Journal Editor-in-Chief
2016-12-19 15:09
Accepted by Company Editor-in-Chief
2016-12-21 16:20
Articles in Press
2016-12-21 16:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-12-25 15:41
Publish the Manuscript Online
2017-01-05 11:10
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Randomized Controlled Trial
Article Title Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial
Manuscript Source Invited Manuscript
All Author List Tisha R Joy, Charles A McKenzie, Rommel G Tirona, Kelly Summers, Shannon Seney, Subrata Chakrabarti, Neel Malhotra and Melanie D Beaton
Funding Agency and Grant Number
Funding Agency Grant Number
Physicians' Services Incorporate Foundation 10q2083
Academic Medical Organization of Southwestern Ontario F10-002
Program of Experimental Medicine and Department of Medicine Academic (partly)
Funds from Western University, London, Ontario, Canada (partly)
Corresponding author Dr. Melanie D Beaton, Associate Professor, Department of Medicine, Division of Gastroenterology, London Health Sciences Centre, Western University, 339 Windermere Road, London, Ontario N6A 5A5, Canada. melanie.beaton@lhsc.on.ca
Keywords Sitagliptin; Randomized controlled trial; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Fibrosis; Magnetic resonance imaging; Hepatic steatosis; Insulin resistance; Platelet aggregation
Core Tip Presently, there is no approved medical therapy for non-alcoholic steatohepatitis (NASH). In this randomized placebo-controlled trial, the effect of sitagliptin on liver fibrosis in patients with NASH after 24 wk was evaluated. There was no significant improvement with the use of sitagliptin on liver fibrosis, total non-alcoholic fatty liver disease activity score or its individual components. Similarly, there were no significant improvements in liver enzymes, adipocytokines, lipid profile, thrombosis parameters, or adipose distribution. There was a strong correlation between hepatic fat % measured using the MRI IDEAL technique and hepatic steatosis on liver biopsy.
Publish Date 2017-01-05 11:10
Citation Joy TR, McKenzie CA, Tirona RG, Summers K, Seney S, Chakrabarti S, Malhotra N, Beaton MD. Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial. World J Gastroenterol 2017; 23(1): 141-150
Url http://www.wjgnet.com/1007-9327/full/v23/i1/141.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i1.141
Full Article (PDF) WJG-23-141.pdf
Full Article (Word) WJG-23-141.doc
Manuscript File 30371-Review.doc
Answering Reviewers 30371-Answering reviewers.pdf
Audio Core Tip 30371-Audio core tip.mp3
Biostatistics Review Certificate 30371-Biostatistics statement.pdf
Clinical Trial Registration Statement 30371-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 30371-Conflict-of-interest statement.pdf
Copyright License Agreement 30371-Copyright assignment.pdf
Data Sharing Statement 30371-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 30371-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 30371-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document 30371-Institutional review board statement.pdf
Scientific Research Process 30371-Scientific research process.pdf
Peer-review Report 30371-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 30371-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 30371-Scientific misconduct check.pdf
Scientific Editor Work List 30371-Scientific editor work list.pdf