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Articles Published Processes
4/7/2017 8:24:12 AM | Browse: 1582 | Download: 2624
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Received |
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2016-09-29 16:32 |
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Peer-Review Started |
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2016-10-07 21:01 |
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To Make the First Decision |
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2016-12-01 14:16 |
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Return for Revision |
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2016-12-06 19:50 |
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Revised |
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2016-12-20 21:21 |
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Second Decision |
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2017-02-15 18:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-03-02 08:16 |
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Articles in Press |
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2017-03-02 08:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-03-30 14:43 |
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Publish the Manuscript Online |
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2017-04-07 08:24 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Frontier |
| Article Title |
Leptin signaling and cancer chemoresistance: Perspectives
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Pierre V Candelaria, Antonio Rampoldi, Adriana Harbuzariu and Ruben R Gonzalez-Perez |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institute of Health (NIH)/National Cancer Institute (NCI) |
1R41CA183399-01A1 |
| Department of Defense (DOD), Congressionally Direct Medical Research Program (CDMRP) |
W81XWH-13-1-0382 |
| Pilot Project Award from MSM (Morehouse School of Medicine)/Tuskegee University/University of Alabama in Birmingham (UAB) Cancer Center partnership |
5U54CA118638 |
| National Institute on Minority Health and Health Disparities (NIMHD) of NIH |
5S21MD00101 |
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| Corresponding Author |
Ruben R Gonzalez-Perez, PhD, Professor, Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Hugh Gloster Bldg., Room 329, Atlanta, GA 30310, United States. rgonzalez@msm.edu |
| Key Words |
Obesity-related cancer; Cancer stem cells; Leptin; Chemoresistance; Breast cancer; Pancreatic cancer |
| Core Tip |
Obesity and its main mediator leptin, are implicated in many protumorigenic processes, with emerging evidence from both the literature and our work pointing to a significant role in the development of resistance to chemotherapies. Chemoresistance is a major concern in the field of cancer therapy as some cancers have no targeted therapies available. As obesity reaches epidemic proportions around the world, its impact on diseases like cancer and its treatment becomes more relevant. In this paper, we will discuss the current state of the literature regarding the influence of obesity and leptin on cancer treatment and the development of chemoresistance. |
| Publish Date |
2017-04-07 08:24 |
| Citation |
Candelaria PV, Rampoldi A, Harbuzariu A, Gonzalez-Perez RR. Leptin signaling and cancer chemoresistance: Perspectives. World J Clin Oncol 2017; 8(2): 106-119 |
| URL |
http://www.wjgnet.com/2218-4333/full/v8/i2/106.htm |
| DOI |
http://dx.doi.org/10.5306/wjco.v8.i2.106 |
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