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Articles Published Processes
3/13/2017 7:05:00 PM | Browse: 1151 | Download: 3986
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Received |
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2016-09-29 16:42 |
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Peer-Review Started |
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2016-10-01 14:19 |
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To Make the First Decision |
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2016-12-02 08:34 |
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Return for Revision |
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2016-12-06 17:02 |
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Revised |
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2016-12-21 11:26 |
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Second Decision |
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2017-02-06 14:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-02-08 10:47 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-02-25 11:08 |
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Typeset the Manuscript |
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2017-03-06 16:27 |
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Publish the Manuscript Online |
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2017-03-13 19:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
miR-34a mediates oxaliplatin resistance of colorectal cancer cells by inhibiting macroautophagy via transforming growth factor-β/Smad4 pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chen Sun, Fu-Jing Wang, Hao-Gang Zhang, Xun-Zheng Xu, Rui-Chun Jia, Lei Yao and Peng-Fei Qiao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science Foundation of Education Department of Heilongjiang Province, China |
12541430 |
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| Corresponding Author |
Dr. Peng-Fei Qiao, Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province,
China. lunwenqpf@126.com
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| Key Words |
miR-34a; Oxaliplatin; Colorectal cancer; Macroautophagy; Transforming growth factor-β/Smad pathway |
| Core Tip |
This study demonstrated a significant association between microRNA (miR)-34a expression and the acquired chemoresistance to oxaliplatin (OXA) in colorectal cancer (CRC). miR-34a mediates OXA resistance through its inhibitory effects on macroautophagy by the transforming growth factor (TGF)-β/Smad4 pathway. Our findings suggest that miR-34a is a potential therapeutic target for improving the chemotherapeutic effect of OXA in CRC.
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| Publish Date |
2017-03-13 19:06 |
| Citation |
Sun C, Wang FJ, Zhang HG, Xu XZ, Jia RC, Yao L, Qiao PF. miR-34a mediates oxaliplatin resistance of colorectal cancer cells by inhibiting macroautophagy via transforming growth factor-β/Smad4 pathway. World J Gastroenterol 2017; 23(10): 1816-1827 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i10/1816.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i10.1816 |
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