Publication Name	World Journal of Hepatology
Manuscript ID	30380
Country	United Kingdom

Received	2016-09-30 10:09
Peer-Review Started	2016-10-02 09:39
To Make the First Decision	2016-10-20 08:53
Return for Revision	2016-10-31 09:23
Revised	2016-11-23 21:13
Second Decision	2017-01-20 10:47
Accepted by Journal Editor-in-Chief	2017-01-23 05:50
Accepted by Executive Editor-in-Chief	2017-02-13 14:09
Articles in Press	2017-02-13 14:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-23 09:34
Publish the Manuscript Online	2017-02-27 08:50

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Hepatorenal syndrome: Update on diagnosis and therapy
Manuscript Source	Invited Manuscript
All Author List	Juan G Acevedo and Matthew E Cramp
Funding Agency and Grant Number
Corresponding Author	Juan G Acevedo, MD, PhD, South West Liver Unit, Plymouth Hospitals Trust, Derriford Road, Plymouth, Devon PL6 8DH, United Kingdom. jacevedo@nhs.net
Key Words	Hepatorenal syndrome; Acute-on-chronic liver failure; Liver cirrhosis; Terlipressin; Acute kidney injury
Core Tip	Hepatorenal syndrome (HRS) is a life-threa-tening complication present in very advanced liver cirrhosis. This manuscript addresses many recent advances in this field, including the recent change in the definition of HRS according to acute kidney injury criteria, the potential consequences of the adoption of this new definition, and the use of biomarkers to help in the diagnostic algorithm. Moreover, it reviews the recent advances in treatment of HRS such as the use of continuous infusion of terlipressin instead of bolus and the low efficacy of midodrine plus octreotide. Potential areas of research are identified as well.
Publish Date	2017-02-27 08:50
Citation	Acevedo JG, Cramp ME. Hepatorenal syndrome: Update on diagnosis and therapy. World J Hepatol 2017; 9(6): 293-299
URL	http://www.wjgnet.com/1948-5182/full/v9/i6/293.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i6.293

Full Article (PDF)	WJH-9-293.pdf
Full Article (Word)	WJH-9-293.doc
Manuscript File	30380-Review.docx
Answering Reviewers	30380-Answering reviewers.pdf
Audio Core Tip	30380-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	30380-Conflict-of-interest statement.pdf
Copyright License Agreement	30380-Copyright assignment.pdf
Peer-review Report	30380-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	30380-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	30380-Scientific misconduct check.pdf
Scientific Editor Work List	30380-Scientific editor work list.pdf