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Articles Published Processes
9/3/2014 5:13:00 PM | Browse: 800 | Download: 743
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Received |
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2013-04-07 10:31 |
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Peer-Review Started |
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2013-04-17 12:19 |
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To Make the First Decision |
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2013-06-09 10:14 |
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Return for Revision |
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2013-06-13 15:40 |
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Revised |
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Second Decision |
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2013-09-05 11:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2013-09-05 12:47 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-01-08 19:51 |
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Publish the Manuscript Online |
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2014-01-26 20:08 |
Category |
Medicine, Research & Experimental |
Manuscript Type |
Autobiography |
Article Title |
Portal inflow preservation during portal diversion in small-for-size syndrome
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Manuscript Source |
Invited Manuscript |
All Author List |
Xian-Qiang Wang, Yue-Fang Xu, Jing-Wang Tan, Wen-Ping Lv, Zhe Liu, Jian-Ping Zeng and Jia-Hong Dong |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Chinese Ministry of Health |
200802012 |
National Natural Science Foundation of China |
81271738 |
National Science and Technology Major Project of China |
2012BAI06B01 |
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Corresponding Author |
Jia-Hong Dong, MD, PhD, FACS, Department of Hepatobiliary Surgery, the Chinese PLA General Hospital, Beijing, China. dongjh_301@163.com
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Key Words |
Portal flow; Portal diversion; Small-for-size syndrome; Mesocaval shunt |
Core Tip |
We established a model of small-for-size syndrome in pigs undergoing 85%-90% hepatectomy with mesocaval shunt (MCS) placement to define the optimal portal inflow required to preserve liver regeneration. Our findings indicate that diversion of portal inflow by MCS reduces injury from portal overflow following major hepatectomy, whereas excessive diversion of portal flow can retard liver regeneration. Preservation of portal inflow to at least 3.2 times above baseline levels appeared to promote hepatocyte hypertrophy and reduce apoptosis.
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Publish Date |
2014-01-26 20:08 |
Citation |
Wang XQ, Xu YF, Tan JW, Lv WP, Liu Z, Zeng JP, Dong JH. Portal inflow preservation during portal diversion in small-for-size syndrome. World J Gastroenterol 2014; 20(4): 1021-1029 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i4/1021.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i4.1021 |
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