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Articles Published Processes
1/22/2017 11:39:00 AM | Browse: 1019 | Download: 1458
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Received |
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2016-10-06 20:04 |
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Peer-Review Started |
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2016-10-07 18:45 |
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To Make the First Decision |
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2016-10-28 13:20 |
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Return for Revision |
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2016-11-02 19:30 |
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Revised |
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2016-11-13 02:34 |
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Second Decision |
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2016-12-25 10:13 |
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Accepted by Journal Editor-in-Chief |
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2016-12-25 16:33 |
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Accepted by Executive Editor-in-Chief |
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2017-01-03 12:04 |
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Articles in Press |
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2017-01-03 12:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-01-09 14:34 |
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Publish the Manuscript Online |
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2017-01-22 11:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Impact of humic acids on the colonic microbiome in healthy volunteers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alexander Swidsinski, Yvonne Dörffel, Vera Loening-Baucke, Christoph Gille, Anne Reißhauer, Onder Göktas, Monika Krüger, Jürgen Neuhaus and Wieland Schrödl |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Alexander Swidsinski, Laboratory for Molecular Genetics, Polymicrobial Infections and Biofilms, Department of Medicine, Section of Gastroenterology, Hepatology and Endocrinology, Charité Universitätsmedizin Berlin, 10098 Berlin, Germany. alexander.swidsinski@charite.de |
| Key Words |
Fluorescence in situ hybridization; Colonic microbiota; Colonic bioreactor; Humic acids; Healthy volunteers; Oral supplementation |
| Core Tip |
Modern patients are increasingly interested in natural medicinal products, which are often not scientifically evaluated. Humins arise from organic microbial degradation and are an important mediator of microbial interactions in nature. Although used for medical indications since ancient times, no data exist on the impact of humins on the human microbiome. Our investigations in healthy volunteers show that orally applied humic acids increase the sum concentrations of preexisting colonic microbiota from 20% to 30% without changes in the bacterial diversity of the individual microbiome and may be a serious amendment/alternative to fecal transplantation or probiotics. |
| Publish Date |
2017-01-22 11:39 |
| Citation |
Swidsinski A, Dörffel Y, Loening-Baucke V, Gille C, Reißhauer A, Göktas O, Krüger M, Neuhaus J, Schrödl W. Impact of humic acids on the colonic microbiome in healthy volunteers. World J Gastroenterol 2017; 23(5): 885-890 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i5/885.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i5.885 |
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