Publication Name	World Journal of Gastroenterology
Manuscript ID	30486
Country	Germany

Received	2016-10-06 19:10
Peer-Review Started	2016-10-08 19:15
To Make the First Decision	2016-10-20 14:41
Return for Revision	2016-10-25 16:48
Revised	2016-12-13 12:48
Second Decision	2017-02-06 14:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-02-08 10:51
Articles in Press	2017-02-08 10:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-22 17:58
Publish the Manuscript Online	2017-03-06 13:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Basic Study
Article Title	hsa-mir-183 is frequently methylated and related to poor survival in human hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Sumadi Lukman Anwar, Till Krech, Britta Hasemeier, Elisa Schipper, Nora Schweitzer, Arndt Vogel, Hans Kreipe, Reena Buurman, Britta Skawran and Ulrich Lehmann
Funding Agency and Grant Number	Funding Agency Grant Number Deutsche Forschungsgemeinschaft (DFG) SFB-TRR77 “Liver cancer” (Project B1)
Corresponding Author	Dr. Ulrich Lehmann, professor, Institute of Pathology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany. lehmann.ulrich@mh-hannover.de
Key Words	hsa-miR-183; DNA methylation; DNMT knockdown; microRNA microarray
Core Tip	A comprehensive screening using microRNA microarray in hepatocellular carcinoma (HCC) cells after DNMT1-, DNMT3A-, and/or DNMT3B-knockdown revealed upregulation of miR-23, miR-25, and miR-183. Using primary HCC tumor tissues, we confirmed frequent DNA hypermethylation at the hsa-mir-183 promoter. Hypermethylation of hsa-miR-183 was not found in benign liver tumors, adjacent tumor tissues as well as healthy livers and significantly correlated with poor prognosis. Therefore it represents a potential novel diagnostic and prognostic marker in HCC.
Publish Date	2017-03-06 13:24
Citation	Anwar SL, Krech T, Hasemeier B, Schipper E, Schweitzer N, Vogel A, Kreipe H, Buurman R, Skawran B, Lehmann U. hsa-mir-183 is frequenty methylated and related to poor survival in human hepatocellular carcinoma. World J Gastroenterol 2017; 23(9): 1568-1575
URL	http://www.wjgnet.com/1007-9327/full/v23/i9/1568.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i9.1568

Full Article (PDF)	WJG-23-1568.pdf
Full Article (Word)	WJG-23-1568.doc
Manuscript File	30486-Review.doc
Answering Reviewers	30486-Answering reviewers.pdf
Audio Core Tip	30486-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	30486-Conflict-of-interest statement.pdf
Copyright License Agreement	30486-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	30486-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	30486-Institutional review board statement.pdf
Supplementary Material	30486-Supplementary material.pdf
Peer-review Report	30486-Peer-review(s).pdf
Scientific Misconduct Check	30486-Scientific misconduct check.pdf
Scientific Editor Work List	30486-Scientific editor work list.pdf