Publication Name	World Journal of Transplantation
Manuscript ID	30496
Country	Germany

Received	2016-10-07 16:18
Peer-Review Started	2016-10-07 17:46
To Make the First Decision	2016-11-11 09:34
Return for Revision	2016-11-15 17:53
Revised	2016-11-22 05:57
Second Decision	2016-12-29 16:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-01-14 15:25
Articles in Press	2017-01-14 15:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-20 13:27
Publish the Manuscript Online	2017-02-21 17:21

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Minireviews
Article Title	Influence of tacrolimus metabolism rate on renal function after solid organ transplantation
Manuscript Source	Invited Manuscript
All Author List	Gerold Thölking, Hans Ulrich Gerth, Katharina Schuette-Nuetgen and Stefan Reuter
Funding Agency and Grant Number
Corresponding Author	Gerold Thölking, MD, Division of General Internal Medicine, Nephrology and Rheumatology, Department of Medicine D, University Hospital of Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Münster, Germany. gerold.thoelking@ukmuenster.de
Key Words	Tacrolimus; Liver; Metabolism; Transplantation; Kidney
Core Tip	The calcineurin inhibitor tacrolimus (TAC) is the mainstay of the immunosuppressive regimen after solid organ transplantation. Nevertheless, TAC can cause nephrotoxicity even at low blood trough levels. Thus, other factors than the TAC trough level might be responsible for kidney injury. Recently published studies showed a strong association between fast TAC metabolism and nephrotoxicity as well as BK virus infection. The TAC metabolism rate defined as the TAC concentration/dose ratio is a cost neutral tool to identify patients at risk for TAC-associated decline in renal function after transplantation.
Publish Date	2017-02-21 17:21
Citation	Thölking G, Gerth HU, Schuette-Nuetgen K, Reuter S. Influence of tacrolimus metabolism rate on renal function after solid organ transplantation. World J Transplant 2017; 7(1): 26-33
URL	http://www.wjgnet.com/2220-3230/full/v7/i1/26.htm
DOI	http://dx.doi.org/10.5500/wjt.v7.i1.26

Full Article (PDF)	WJT-7-26.pdf
Full Article (Word)	WJT-7-26.doc
Manuscript File	30496-Review.docx
Answering Reviewers	30496-Answering reviewers.pdf
Audio Core Tip	30496-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	30496-Conflict-of-interest statement.pdf
Copyright License Agreement	30496-Copyright assignment.pdf
Peer-review Report	30496-Peer-review(s).pdf
Scientific Misconduct Check	30496-Scientific misconduct check.pdf
Scientific Editor Work List	30496-Scientific editor work list.pdf