Publication Name	World Journal of Medical Genetics
Manuscript ID	30527
Country	Italy

Received	2016-10-07 15:08
Peer-Review Started	2016-10-07 17:32
To Make the First Decision	2016-11-11 09:35
Return for Revision	2016-11-15 17:54
Revised	2016-12-19 23:08
Second Decision	2017-02-08 15:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-02-21 10:37
Articles in Press	2017-02-21 10:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-02-24 09:34
Publish the Manuscript Online	2017-02-27 08:49

ISSN	2220-3184 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Genetics & Heredity
Manuscript Type	Editorial
Article Title	New era of cystic fibrosis: Full mutational analysis and personalized therapy
Manuscript Source	Invited Manuscript
All Author List	Marco Lucarelli
Funding Agency and Grant Number
Corresponding Author	Marco Lucarelli, Associate Professor, BS Specialist in Clinical Pathology, Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Viale Regina Elena 324, 00161 Rome, Italy. marco.lucarelli@uniroma1.it
Key Words	Genotype - phenotype relationship; CFTR; Cystic fibrosis; Next generation sequencing; Functional meaning of mutations; Personalized therapy; Mutation search; Mutation functional classes
Core Tip	Cystic fibrosis (CF) is the most common severe monogenic disease of Caucasian population. Despite its apparently simple genetics, it has a complex genotype - phenotype relationship. This is mainly due to the high number of mutations of the causing gene (the CFTR) and to the complexity of the CFTR cellular network. The next generation sequencing approach allows a full genetic characterization of the CFTR and CFTR network improving our diagnostic, prognostic and therapeutic ability. This is coupled to the availability of drugs acting on specific mutational classes. The synergy between massive sequencing and personalized therapy is expected to produce an unparalleled advantage for CF patients.
Publish Date	2017-02-27 08:49
Citation	Lucarelli M. new era of cystic fibrosis: Full mutational analysis and personalized therapy. World J Med Genet 2017; 7(1): 1-9
URL	http://www.wjgnet.com/2220-3184/full/v7/i1/1.htm
DOI	http://dx.doi.org/10.5496/wjmg.v7.i1.1

Full Article (PDF)	WJMG-7-1.pdf
Full Article (Word)	WJMG-7-1.doc
Manuscript File	30527-Review.docx
Answering Reviewers	30527-Answering reviewers.pdf
Audio Core Tip	30527-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	30527-Conflict-of-interest statement.pdf
Copyright License Agreement	30527-Copyright assignment.PDF
Peer-review Report	30527-Peer-review(s).pdf
Scientific Misconduct Check	30527-Scientific misconduct check.pdf
Scientific Editor Work List	30527-Scientific editor work list.pdf