Publication Name	World Journal of Hepatology
Manuscript ID	3061
Country	Denmark

Received	2013-04-05 10:52
Peer-Review Started	2013-04-06 16:30
To Make the First Decision	2013-05-14 18:43
Return for Revision	2013-05-17 15:34
Revised	2013-06-08 06:05
Second Decision	2013-08-20 10:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-20 12:38
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-03 08:32
Publish the Manuscript Online	2013-10-01 17:51

ISSN	1948-5182 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Ciclosporin does not attenuate intracranial hypertension in rats with acute hyperammonaemia
Manuscript Source	Invited Manuscript
All Author List	Rikke Hebo Larsen, Mette S Kjær, Martin Eefsen, Fin Stolze Larsen and Peter Nissen Bjerring
Funding Agency and Grant Number
Corresponding Author	Peter Nissen Bjerring, PhD, Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark. peterbjerring@gmail.com
Key Words	Brain oedema; Acute liver failure; Neuroprotection; Hyperammonaemia; Ciclosporin
Core Tip	Acute liver failure and hyperammonaemia can lead to severe brain oedema. Preserving mitochondrial function by treatment with ciclosporin has shown potential in in vitro studies. In this study we evaluated the effect of ciclosporin in a rat model of acute hyperammonaemia on intracranial pressure, brain water content and expression of the water channel aquaporin-4. We did not find a beneficial effect of ciclosporin on intracranial pressure, brain water content or aquaporin-4 expression.
Publish Date	2013-10-01 17:51
Citation	Larsen RH, Kj?r MS, Eefsen M, Larsen FS, Bjerring PN. Ciclosporin does not attenuate intracranial hypertension in rats with acute hyperammonaemia. World J Hepatol 2013; 5(9): 513-520
URL	http://www.wjgnet.com/1948-5182/full/v5/i9/513.htm
DOI	http://dx.doi.org/10.4254/wjh.v5.i9.513

Full Article (PDF)	WJH-5-513.pdf
Manuscript File	3061-Review.doc
Answering Reviewers	3061-Answering reviewers.pdf
Copyright License Agreement	3061-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3061-Language certificate.pdf
Peer-review Report	3061-Peer reviews.pdf
Scientific Editor Work List	3061-Scientific editor work list.doc