Publication Name	World Journal of Gastroenterology
Manuscript ID	3063
Country	United States

Received	2013-04-05 11:08
Peer-Review Started	2013-04-06 16:26
To Make the First Decision	2013-04-16 09:06
Return for Revision	2013-04-20 16:08
Revised	2013-05-13 04:27
Second Decision	2013-07-18 15:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-19 03:55
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-09 09:58
Publish the Manuscript Online	2013-08-27 16:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	DNA methylation in inflammatory bowel disease and beyond
Manuscript Source	Invited Manuscript
All Author List	Daren Low, Atsushi Mizoguchi and Emiko Mizoguchi
Funding Agency and Grant Number	Funding Agency Grant Number National Institute of Health DK80070 National Institute of Health DK74454 National Institute of Health DK64289 Eli and Edythe L. Broad Medical Foundation and American Gastroenterological Association Foundation to Mizoguchi E Singapore A*STAR Graduate Academy BM/AIF/13/001 (to Low D)
Corresponding Author	Emiko Mizoguchi, MD, PhD, Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, GRJ 825D, 55 Fruit Street, Boston, MA 02114, United States. emizoguchi@partners.org
Key Words	Intestinal inflammation; Crohn's disease; Colitis; DNA methyltransferase; Epi-therapy
Core Tip	This review discuss the recent research advancement in the area of DNA methylation during the pathogenesis of inflammatory bowel disease (IBD) and IBD-associated cancer, with a focus on highlighting major players mediating DNA methylation alterations during IBD development. Temporal and spatial differential DNA methylation status that contributes to the disease, as well as epi-therapy treatment options for IBD patients, are also discussed. This emerging information will have important clinical significance, especially so in this post-genome-wide association studies era of IBD research.
Publish Date	2013-08-27 16:46
Citation	Low D, Mizoguchi A, Mizoguchi E. DNA methylation in inflammatory bowel disease and beyond. World J Gastroenterol 2013; 19(32): 5238-5249
URL	http://www.wjgnet.com/1007-9327/full/v19/i32/5238.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i32.5238

Full Article (PDF)	WJG-19-5238.pdf
Manuscript File	3063-Review.doc
Answering Reviewers	3063-Answering reviewers.pdf
Copyright License Agreement	3063-Copyright assignment.pdf
Peer-review Report	3063-Peer review(s).pdf
Scientific Editor Work List	3063-Scientific editor work list.doc