Publication Name	World Journal of Hepatology
Manuscript ID	30675
Country	Germany

Received	2016-10-13 16:08
Peer-Review Started	2016-10-17 10:32
To Make the First Decision	2016-11-10 08:40
Return for Revision	2016-11-14 15:18
Revised	2016-11-24 01:38
Second Decision	2016-12-06 11:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-12-14 17:00
Articles in Press	2016-12-14 17:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-07 10:19
Publish the Manuscript Online	2017-03-13 13:20

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Meta-Analysis
Article Title	Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Wasco Wruck and James Adjaye
Funding Agency and Grant Number	Funding Agency Grant Number The medical faculty of the Heinrich Heine University Düsseldorf
Corresponding Author	James Adjaye, PhD, Professor, Medical Faculty, Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany. james.adjaye@med.uni-duesseldorf.de
Key Words	Non-alcoholic fatty liver disease; Alcoholic liver disease cholesterol; Bile; Alcohol dehydrogenase; CYP7A1
Core Tip	With a meta-analysis of newly published liver biopsy-derived transcriptome datasets we identified multiple key genes and pathways in common and mutually exclusive in alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). We provide a compendium of comparative regulation for all KEGG pathways in both diseases and propose a list of biomarkers distinguishing both diseases. One surprising finding was that chole-sterol metabolism was up-regulated in NAFLD and down-regulated in ALD although leading to the same steatosis phenotype which might be explained by an insufficient conversion rate to bile acids under both conditions.
Publish Date	2017-03-13 13:20
Citation	Wruck W, Adjaye J. Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease. World J Hepatol 2017; 9(8): 443-454
URL	http://www.wjgnet.com/1948-5182/full/v9/i8/443.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i8.443

Full Article (PDF)	WJH-9-443.pdf
Full Article (Word)	WJH-9-443.doc
Manuscript File	30675-Review.doc
Answering Reviewers	30675-Answering reviewers.pdf
Audio Core Tip	30675-Audio core tip.mp3
Biostatistics Review Certificate	30675-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	30675-Conflict-of-interest statement.pdf
Copyright License Agreement	30675-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	30675-Grant application form(s).pdf
Supplementary Material	Supplementary_Material_20161012002429.doc
Peer-review Report	30675-Peer-review(s).pdf
Scientific Misconduct Check	30675-Scientific misconduct check.pdf
Scientific Editor Work List	30675-Scientific editor work list.pdf