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Publication Name World Journal of Orthopedics
Manuscript ID 30692
Country/Territory Germany
2016-10-13 09:32
Peer-Review Started
2016-10-17 11:41
To Make the First Decision
2016-12-14 08:42
Return for Revision
2016-12-15 11:16
2017-01-10 09:00
Second Decision
2017-01-22 16:43
Accepted by Journal Editor-in-Chief
2017-01-23 00:27
Accepted by Company Editor-in-Chief
2017-02-13 13:35
Articles in Press
2017-02-13 13:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-04-10 20:57
Publish the Manuscript Online
2017-04-17 19:22
ISSN 2218-5836 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Clinical Trials Study
Article Title RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening
Manuscript Source Invited Manuscript
All Author List Max J Friedrich, Matthias D Wimmer, Jan Schmolders, Andreas C Strauss, Milena M Ploger, Hendrik Kohlhof, Dieter C Wirtz, Sascha Gravius and Thomas M Randau
Funding Agency and Grant Number
Funding Agency Grant Number
Deutsche Arthrose-Hilfe e.V. P192-A362-2009-12
Corresponding author Thomas M Randau, MD, Department of Orthopedics and Trauma Surgery, University Clinic of Bonn, Sigmund Freud Str. 25, 53125 Bonn, Germany. thomas.randau@ukbonn.de
Keywords Aseptic loosening; Diagnostic; RANK-ligand; Periprosthetic joint infection; Biomarker; Osteoprotegerin
Core Tip No statistically significant differences in the serum concentration of RANK-ligand (RANKL) and osteoprotegerin (OPG) were found between aseptic loosening and periprosthetic joint infection (PJI) with a certain trend of lower concentrations in the PJI group. Nevertheless, a RANKL/OPG ratio > 60 ruled out PJI in all cases. In the differentiation between a stable and loose implant the parameters measured showed no significant difference, which let to the conclusion that the sole use of these parameters for differentiating PJI and aseptic loosening cannot be recommended. RANK and OPG may have utility as a conformation test but are not an effective screening parameter for the discrimination of PJI and AL.
Publish Date 2017-04-17 19:22
Citation Friedrich MJ, Wimmer MD, Schmolders J, Strauss AC, Ploger MM, Kohlhof H, Wirtz DC, Gravius S, Randau TM. RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening. World J Orthop 2017; 8(4): 342-349
Url http://www.wjgnet.com/2218-5836/full/v8/i4/342.htm
DOI http://dx.doi.org/10.5312/wjo.v8.i4.342
Full Article (PDF) WJO-8-342.pdf
Full Article (Word) WJO-8-342.doc
Manuscript File 30692-Review.docx
Answering Reviewers 30692-Answering reviewers.pdf
Audio Core Tip 30692-Audio core tip.mp3
Biostatistics Review Certificate 30692-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 30692-Conflict-of-interest statement.pdf
Copyright License Agreement 30692-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 30692-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20161012215058.pdf
Institutional Review Board Approval Form or Document 30692-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 30692-Language certificate.pdf
Scientific Research Process 30692-Scientific research process.pdf
Peer-review Report 30692-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 30692-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 30692-Scientific misconduct check.pdf
Scientific Editor Work List 30692-Scientific editor work list.pdf