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Articles Published Processes
1/12/2017 1:49:00 PM | Browse: 1256 | Download: 2236
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Received |
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2016-10-13 08:37 |
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Peer-Review Started |
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To Make the First Decision |
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Return for Revision |
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Revised |
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Second Decision |
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2016-10-25 20:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-10-31 15:10 |
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Articles in Press |
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2016-10-31 15:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-11-21 15:25 |
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Typeset the Manuscript |
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2016-12-31 18:55 |
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Publish the Manuscript Online |
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2017-01-12 13:49 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Association between polymorphisms of the APOBEC3G gene and chronic hepatitis B viral infection and hepatitis B virus-related hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiu-Ting He, Hong-Qin Xu, Xiao-Mei Wang, Xiu-Shu He, Jun-Qi Niu and Pu-Jun Gao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science and Technology Major Project |
2014ZX10002002 |
| National Basic Research Program of China (973 Program) |
2015CB554304 |
| National Natural Science Foundation of China |
81373057 |
| National Natural Science Foundation of China |
81301472 |
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| Corresponding Author |
Dr. Pu-Jun Gao, Vice Director, Department of Hepatology, The First Hospital of Jilin University, No 71 Xinmin Street, Changchun 130021, Jilin Province, China. pujun-gao@163.com |
| Key Words |
Hepatitis B viral; Hepatocellular carcinoma; APOBEC3s; Polymorphism; Progression |
| Core Tip |
A3G is a dominant cytidine deaminase that strongly inhibits synthesis and editing of hepatitis B virus (HBV) DNA. We studied the relationship between five A3G gene single nucleotide polymorphisms and the incidence of chronic HBV infection (CHB) and hepatocellular carcinoma (HCC), including 657 CHB patients (287 HCC and 370 non-HCC) and 299 healthy controls. The AG genotype and G allele for rs8177832 were potentially protective factors against CHB and HCC. Computed tomography and TT genotypes of rs2011861 were risk factors for HCC. Haplotype analyses showed three protective and four risk haplotypes for HCC. Also, one protective haplotype was found against CHB. |
| Publish Date |
2017-01-12 13:49 |
| Citation |
He XT, Xu HQ, Wang XM, He XS, Niu JQ, Gao PJ. Association between polymorphisms of the APOBEC3G gene and chronic hepatitis B viral infection and hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2017; 23(2): 232-241 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i2/232.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i2.232 |
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