Publication Name	World Journal of Gastroenterology
Manuscript ID	30721
Country	India

Received	2016-10-14 09:53
Peer-Review Started	2016-10-14 21:49
To Make the First Decision	2016-12-01 15:41
Return for Revision	2016-12-02 17:16
Revised	2016-12-16 17:58
Second Decision	2016-12-29 10:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-01-04 16:30
Articles in Press	2017-01-04 16:30
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-01-17 13:36
Typeset the Manuscript	2017-02-10 15:47
Publish the Manuscript Online	2017-02-20 17:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Chemistry, Medicinal
Manuscript Type	Basic Study
Article Title	Investigation of mitigating effect of colon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in Wistar rats: Design, kinetics and biological evaluation
Manuscript Source	Invited Manuscript
All Author List	Ajinkya Sarkate and Suneela S Dhaneshwar
Funding Agency and Grant Number
Corresponding Author	Suneela S Dhaneshwar, PhD, Professor, Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune, Maharashtra 411038, India. suneeladhaneshwar@rediffmail.com
Key Words	Inflammatory bowel disease; Boswellic acid; Complementary and alternative medicine; Colon-targeting; Mutual prodrugs; Amino acids; TNBS-induced colitis
Core Tip	Boswellic acids (BAs) are traditionally used in the treatment of inflammatory diseases and are effective in the treatment of inflammatory bowel disease (IBD) in particular, but they undergo extensive metabolism that results in low oral bioavailability. Colon-targeted delivery of BA was achieved by designing prodrugs that deliver BA site-specifically. The synthesized prodrugs were designed by semi-synthetic approach, wherein β-boswellic acid (BBA) was derivatized into a bioreversible delivery system by incorporation of amino acids as promoities for targeted delivery to inflamed colon in IBD. Prodrug of BBA with L-tryptophan (BT) was 1.7-times more effective than sulfasalazine (SLZ) in 2,4,6-trinitrobenzene sulfonic acid-induced colitis in Wistar rats. In vivo behavior of prodrug BT was very interesting and similar to SLZ, which is known to treat local inflammation in IBD as well as in rheumatoid arthritis (RA). The outcome of this study strongly suggests that these prodrugs might have dual applicability to IBD and chronotherapy of RA.
Publish Date	2017-02-20 17:58
Citation	Sarkate A, Dhaneshwar SS. Investigation of mitigating effect of colon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in Wistar rats: Design, kinetics and biological evaluation. World J Gastroenterol 2017; 23(7): 1147-1162
URL	http://www.wjgnet.com/1007-9327/full/v23/i7/1147.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i7.1147

Full Article (PDF)	WJG-23-1147.pdf
Full Article (Word)	WJG-23-1147.doc
Manuscript File	30721-Review.doc
Answering Reviewers	30721-Answering reviewers.pdf
Audio Core Tip	30721-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	30721-Conflict-of-interest statement.pdf
Copyright License Agreement	30721-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	30721-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	30721-Institutional review board statement.pdf
Peer-review Report	30721-Peer-review(s).pdf
Scientific Misconduct Check	30721-Scientific misconduct check.pdf
Scientific Editor Work List	30721-Scientific editor work list.pdf