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4/13/2017 3:45:15 PM | Browse: 447 | Download: 440
Publication Name World Journal of Hepatology
Manuscript ID 30822
Country/Territory Japan
Received
2016-10-19 10:35
Peer-Review Started
2016-10-23 19:54
To Make the First Decision
2016-12-19 08:47
Return for Revision
2016-12-20 15:46
Revised
2017-01-12 12:46
Second Decision
2017-01-23 12:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-02-13 13:44
Articles in Press
2017-02-13 13:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-03-19 06:52
Typeset the Manuscript
2017-03-28 17:12
Publish the Manuscript Online
2017-04-13 15:45
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Efficacy and safety of dual therapy with daclatasvir and asunaprevir in elderly patients
Manuscript Source Unsolicited Manuscript
All Author List Kazuo Tarao, Katsuaki Tanaka, Akito Nozaki, Akira Sato, Toshiya Ishii, Hirokazu Komatsu, Takaaki Ikeda, Tatsuji Komatsu, Shozo Matsushima and Kenji Oshige
Funding Agency and Grant Number
Corresponding author Kazuo Tarao, MD, Tarao’s Gastro­enterological Clinic, Taiyo-Building, 2-58-6, Futamatagawa, Asahi-ku, Yokohama 241-0821, Japan. nrg18449@nifty.com
Keywords Asunaprevir; Chronic hepatitis; Daclatasvir; Dual oral therapy; Elderly patients; Hepatitis C virus infection; Hepatitis C virus; Liver cirrhosis
Core Tip Recently, it was demonstrated that dual oral therapy with daclatasvir and asunaprevir without pegylated-interferon/ribavirin was well tolerated and achieved high sustained virological response rates in Japanese patients with chronic hepatitis C virus genotype Ιb infection, including patients with liver cirrhosis (Child A stage). However, the efficacy and side effects of these drugs was previously studied in non-elderly patients (less than 70 years of age). Those in elderly patients, who are supposed to have higher incidence of hepatocellular carcinoma, have not been studied. We demonstrated that efficacy and side effects in elderly patients were nearly the same as in non-elderly patients.
Publish Date 2017-04-13 15:45
Citation Tarao K, Tanaka K, Nozaki A, Sato A, Ishii T, Komatsu H, Ikeda T, Komatsu T, Matsushima S, Oshige K. Efficacy and safety of dual therapy with daclatasvir and asunaprevir in elderly patients. World J Hepatol 2017; 9(11): 544-550
Url http://www.wjgnet.com/1948-5182/full/v9/i11/544.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i11.544
Full Article (PDF) WJH-9-544.pdf
Full Article (Word) WJH-9-544.doc
Manuscript File 30822-Review.docx
Answering Reviewers 30822-Answering reviewers.pdf
Audio Core Tip 30822-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 30822-Conflict-of-interest statement.pdf
Copyright License Agreement 30822-Copyright assignment.pdf
Data Sharing Statement 30822-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20161018115813.docx
Institutional Review Board Approval Form or Document 30822-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 30822-Language certificate.pdf
Peer-review Report 30822-Peer-review(s).pdf
Scientific Misconduct Check 30822-Scientific misconduct check.pdf
Scientific Editor Work List 30822-Scientific editor work list.pdf