| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Sodium selenite ameliorates dextran sulfate sodium-induced chronic colitis in mice by decreasing Th1, Th17, and γδT and increasing CD4(+)CD25(+) regulatory T-cell responses
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Xuan Sang, Bing Chang, Jun-Feng Zhu, Fang-Li Yang, Yan Li, Xue-Feng Jiang, Da-Nan Wang, Chang-Long Lu and Xun Sun |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
31370921 |
| Natural Science Foundation of Liaoning Province |
2015020515 |
|
| Corresponding Author |
Dr. Chang-Long Lu, Professor, Department of Immunology, China Medical University, No. 77, Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning Province, China. cllu@mail.cmu.edu.cn |
| Key Words |
Sodium selenite; Dextran sulfate sodium; Chronic colitis |
| Core Tip |
Se significantly ameliorated the symptoms of colitis and histological injury, increasing the proportions of neutrophils and CD4+ CD25+ T cells and decreasing the proportions of γδT cells, CD4+, CD4+CD44+, and CD4+ CD69+ T cells in LPL. Moreover, Se reduced the expression of IL-6, IFN-γ, IL-17A, IL-21, T-bet, and RORγt, but enhanced the expression of IL-10 and Foxp3. The study suggests that Se protects against DSS-induced chronic colitis perhaps by increasing the number of CD4(+)CD25(+) Tregs that suppress the secretion of proinflammatory cytokines and populations of Th1, Th17, and γδT cells. |
| Publish Date |
2017-06-07 07:22 |
| Citation |
Sang LX, Chang B, Zhu JF, Yang FL, Li Y, Jiang XF, Wang DN, Lu CL, Sun X. Sodium selenite ameliorates dextran sulfate sodium-induced chronic colitis in mice by decreasing Th1, Th17, and γδT and increasing CD4(+)CD25(+) regulatory T-cell responses. World J Gastroenterol 2017; 23(21): 3850-3863 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i21/3850.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i21.3850 |
