6/7/2017 7:22:42 AM | Browse: 951 | Download: 1591
| Publication Name | World Journal of Gastroenterology |
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| Manuscript ID | 30852 |
| Country | China |
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2017-06-07 07:22 |
| ISSN | 1007-9327 (print) and 2219-2840 (online) |
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| Open Access | This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright | © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||||
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| Manuscript Type | Basic Study | ||||||
| Article Title | Sodium selenite ameliorates dextran sulfate sodium-induced chronic colitis in mice by decreasing Th1, Th17, and γδT and increasing CD4(+)CD25(+) regulatory T-cell responses | ||||||
| Manuscript Source | Unsolicited Manuscript | ||||||
| All Author List | Li-Xuan Sang, Bing Chang, Jun-Feng Zhu, Fang-Li Yang, Yan Li, Xue-Feng Jiang, Da-Nan Wang, Chang-Long Lu and Xun Sun | ||||||
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| Corresponding Author | Dr. Chang-Long Lu, Professor, Department of Immunology, China Medical University, No. 77, Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning Province, China. cllu@mail.cmu.edu.cn | ||||||
| Key Words | Sodium selenite; Dextran sulfate sodium; Chronic colitis | ||||||
| Core Tip | Se significantly ameliorated the symptoms of colitis and histological injury, increasing the proportions of neutrophils and CD4+ CD25+ T cells and decreasing the proportions of γδT cells, CD4+, CD4+CD44+, and CD4+ CD69+ T cells in LPL. Moreover, Se reduced the expression of IL-6, IFN-γ, IL-17A, IL-21, T-bet, and RORγt, but enhanced the expression of IL-10 and Foxp3. The study suggests that Se protects against DSS-induced chronic colitis perhaps by increasing the number of CD4(+)CD25(+) Tregs that suppress the secretion of proinflammatory cytokines and populations of Th1, Th17, and γδT cells. | ||||||
| Publish Date | 2017-06-07 07:22 | ||||||
| Citation | Sang LX, Chang B, Zhu JF, Yang FL, Li Y, Jiang XF, Wang DN, Lu CL, Sun X. Sodium selenite ameliorates dextran sulfate sodium-induced chronic colitis in mice by decreasing Th1, Th17, and γδT and increasing CD4(+)CD25(+) regulatory T-cell responses. World J Gastroenterol 2017; 23(21): 3850-3863 | ||||||
| URL | http://www.wjgnet.com/1007-9327/full/v23/i21/3850.htm | ||||||
| DOI | http://dx.doi.org/10.3748/wjg.v23.i21.3850 |
| Full Article (PDF) | WJG-23-3850.pdf |
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| Full Article (Word) | WJG-23-3850.doc |
| Manuscript File | 30852-Review.doc |
| Answering Reviewers | 30852-Answering reviewers.pdf |
| Audio Core Tip | 30852-Audio core tip.mp3 |
| Conflict-of-Interest Disclosure Form | 30852-Conflict-of-interest statement.pdf |
| Copyright License Agreement | 30852-Copyright assignment.pdf |
| Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) | 30852-Grant application form(s).pdf |
| Institutional Animal Care and Use Committee Approval Form or Document | 30852-Institutional animal care and use committee statement.pdf |
| Institutional Review Board Approval Form or Document | 30852-Institutional review board statement.pdf |
| Non-Native Speakers of English Editing Certificate | 30852-Language certificate.pdf |
| Peer-review Report | 30852-Peer-review(s).pdf |
| Scientific Misconduct Check | 30852-Scientific misconduct check.pdf |
| Scientific Editor Work List | 30852-Scientific editor work list.pdf |