| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Connective tissue diseases in primary biliary cirrhosis: A population-based cohort study
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Li Wang, Feng-Chun Zhang, Hua Chen, Xuan Zhang, Dong Xu, Yong-Zhe Li, Qian Wang, Li-Xia Gao, Yun-Jiao Yang, Fang Kong and Ke Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research Special Fund for Public Welfare Industry of Health |
201202004 |
| National Major Scientific and Technological Special Project for “Significant New Drugs Development” |
2012ZX09303006-002 |
| National High Technology Research and Development Program of China |
2011AA020111 |
|
| Corresponding Author |
Feng-Chun Zhang, MD, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 41 Da Mu Cang, Western District, Beijing 100032, China. zhangfccra@yahoo.com.cn |
| Key Words |
Cirrhosis; Biliary; Connective tissue disease; Sjögren’s syndrome; Systemic sclerosis; Raynaud phenomenon |
| Core Tip |
This study demonstrated that primary biliary cirrhosis (PBC) is a complicated disease that not only involves the liver but also often coexists with other connective tissue diseases (CTDs). Evaluation of our cohort of 322 Chinese PBC patients showed that Sj?gren's syndrome was the CTD that most frequently coexisted with PBC. In addition, it was also shown that when CTDs coexist with PBC, the clinical features and the disease course are different from those in patients with PBC alone. Our collective results suggest that Chinese patients with PBC may benefit from assessment of systemic involvement and screening for CTDs through detection of autoantibodies. |
| Publish Date |
2013-08-19 18:22 |
| Citation |
Wang L, Zhang FC, Chen H, Zhang X, Xu D, Li YZ, Wang Q, Gao LX, Yang YJ, Kong F, Wang K. Connective tissue diseases in primary biliary cirrhosis: A population-based cohort study. World J Gastroenterol 2013; 19(31): 5131-5137 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i31/5131.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i31.5131 |
