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3/13/2017 7:05:00 PM | Browse: 856 | Download: 1716
Publication Name World Journal of Gastroenterology
Manuscript ID 30919
Country/Territory China
Received
2016-10-24 10:33
Peer-Review Started
2016-10-25 09:19
To Make the First Decision
2016-12-02 08:16
Return for Revision
2016-12-12 21:55
Revised
2016-12-25 23:42
Second Decision
2017-01-16 13:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-01-17 17:01
Articles in Press
2017-01-17 17:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-02-10 16:27
Typeset the Manuscript
2017-03-07 09:24
Publish the Manuscript Online
2017-03-13 19:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8+CD11c+ cells
Manuscript Source Invited Manuscript
All Author List Hai-Mei Zhao, Fei Han, Rong Xu, Xiao-Ying Huang, Shao-Min Cheng, Min-Fang Huang, Hai-Yang Yue, Xin Wang, Yong Zou, Han-Lin Xu and Duan-Yong Liu
Funding Agency and Grant Number
Funding Agency Grant Number
Projects of National Natural Science Foundation of China 81260595
National Natural Science Foundation of China 81460679
Chinese Scholarship Council and Jiangxi Province as visiting scholar 201408360106
Chinese Scholarship Council and Jiangxi Province as visiting scholar 201408360110
Traditional Chinese Medicine project of Health Department of Jiangxi Province 2015B049
Project of Jiangxi University of Traditional Chinese Medicine JZYC15S13
Corresponding Author Duan-Yong Liu, Associate Professor, Science and Technology College, Jiangxi University of Tradi­tional Chinese Medicine, 819 Xingwan Road, Nanchang 330004, Jiangxi Province, China. liuduanyong@163.com
Key Words CD8; CD11c; Curcumin; Experimental colitis; Therapeutic effect
Core Tip CD11c is highly expressed in CD8+ and CD8- dendritic cells (DCs). Overaccumulation of CD8+ DCs is seen in colonic mucosa in experimental colitis and patients with inflammatory bowel disease (IBD). CD8+CD11c+ cells may be a potential strategy to explore the mechanism of action of drugs in IBD. The immunosuppressant curcumin (Cur) plays a therapeutic role in various immune diseases, including IBD and rheumatoid arthritis. However, it is unclear whether Cur regulates level of CD8+CD11c+ cells to treat IBD. We found that the therapeutic effect of Cur in experimental colitis was closely related to decreased levels of CD8+CD11c+ cells.
Publish Date 2017-03-13 19:06
Citation Zhao HM, Han F, Xu R, Huang XY, Cheng SM, Huang MF, Yue HY, Wang X, Zou Y, Xu HL, Liu DY. Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8+CD11c+ cells. World J Gastroenterol 2017; 23(10): 1804-1815
URL http://www.wjgnet.com/1007-9327/full/v23/i10/1804.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i10.1804
Full Article (PDF) WJG-23-1804.pdf
Full Article (Word) WJG-23-1804.doc
Manuscript File 30919-Review.docx
Answering Reviewers 30919-Answering reviewers.pdf
Audio Core Tip 30919-Audio core tip.m4a
Biostatistics Review Certificate 30919-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 30919-Conflict-of-interest statement.pdf
Copyright License Agreement 30919-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 30919-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 30919-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 30919-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 30919-Language certificate.pdf
Peer-review Report 30919-Peer-review(s).pdf
Scientific Misconduct Check 30919-Scientific misconduct check.pdf
Scientific Editor Work List 30919-Scientific editor work list.pdf