Publication Name	World Journal of Gastroenterology
Manuscript ID	30919
Country	China

Received	2016-10-24 10:33
Peer-Review Started	2016-10-25 09:19
To Make the First Decision	2016-12-02 08:16
Return for Revision	2016-12-12 21:55
Revised	2016-12-25 23:42
Second Decision	2017-01-16 13:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-01-17 17:01
Articles in Press	2017-01-17 17:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-02-10 16:27
Typeset the Manuscript	2017-03-07 09:24
Publish the Manuscript Online	2017-03-13 19:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8+CD11c+ cells
Manuscript Source	Invited Manuscript
All Author List	Hai-Mei Zhao, Fei Han, Rong Xu, Xiao-Ying Huang, Shao-Min Cheng, Min-Fang Huang, Hai-Yang Yue, Xin Wang, Yong Zou, Han-Lin Xu and Duan-Yong Liu
Funding Agency and Grant Number	Funding Agency Grant Number Projects of National Natural Science Foundation of China 81260595 National Natural Science Foundation of China 81460679 Chinese Scholarship Council and Jiangxi Province as visiting scholar 201408360106 Chinese Scholarship Council and Jiangxi Province as visiting scholar 201408360110 Traditional Chinese Medicine project of Health Department of Jiangxi Province 2015B049 Project of Jiangxi University of Traditional Chinese Medicine JZYC15S13
Corresponding Author	Duan-Yong Liu, Associate Professor, Science and Technology College, Jiangxi University of Tradi­tional Chinese Medicine, 819 Xingwan Road, Nanchang 330004, Jiangxi Province, China. liuduanyong@163.com
Key Words	CD8; CD11c; Curcumin; Experimental colitis; Therapeutic effect
Core Tip	CD11c is highly expressed in CD8+ and CD8- dendritic cells (DCs). Overaccumulation of CD8+ DCs is seen in colonic mucosa in experimental colitis and patients with inflammatory bowel disease (IBD). CD8+CD11c+ cells may be a potential strategy to explore the mechanism of action of drugs in IBD. The immunosuppressant curcumin (Cur) plays a therapeutic role in various immune diseases, including IBD and rheumatoid arthritis. However, it is unclear whether Cur regulates level of CD8+CD11c+ cells to treat IBD. We found that the therapeutic effect of Cur in experimental colitis was closely related to decreased levels of CD8+CD11c+ cells.
Publish Date	2017-03-13 19:06
Citation	Zhao HM, Han F, Xu R, Huang XY, Cheng SM, Huang MF, Yue HY, Wang X, Zou Y, Xu HL, Liu DY. Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8+CD11c+ cells. World J Gastroenterol 2017; 23(10): 1804-1815
URL	http://www.wjgnet.com/1007-9327/full/v23/i10/1804.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i10.1804

Full Article (PDF)	WJG-23-1804.pdf
Full Article (Word)	WJG-23-1804.doc
Manuscript File	30919-Review.docx
Answering Reviewers	30919-Answering reviewers.pdf
Audio Core Tip	30919-Audio core tip.m4a
Biostatistics Review Certificate	30919-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	30919-Conflict-of-interest statement.pdf
Copyright License Agreement	30919-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	30919-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	30919-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	30919-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	30919-Language certificate.pdf
Peer-review Report	30919-Peer-review(s).pdf
Scientific Misconduct Check	30919-Scientific misconduct check.pdf
Scientific Editor Work List	30919-Scientific editor work list.pdf