Publication Name	World Journal of Gastroenterology
Manuscript ID	30961
Country	United States

Received	2016-10-25 09:27
Peer-Review Started	2016-10-28 16:34
To Make the First Decision	2016-12-19 09:51
Return for Revision	2016-12-24 16:31
Revised	2017-01-21 05:42
Second Decision	2017-03-17 17:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-03-20 15:09
Articles in Press	2017-03-20 15:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-29 16:06
Publish the Manuscript Online	2017-04-14 18:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Pathogenesis and clinical spectrum of primary sclerosing cholangitis
Manuscript Source	Invited Manuscript
All Author List	Neelam G Gidwaney, Swati Pawa and Kiron M Das
Funding Agency and Grant Number
Corresponding Author	Kiron M Das, MD, PhD, FACP, FRCP, AGAF, FACG, Chief, Professor of Medicine, Division of Gastroenterology and Hepatology, Rutgers-Robert Wood Johnson Medical School, One Robert Wood Johnson Place, Medical Education Building 478B, New Brunswick, NJ 08903, United States. daskm@rwjms.rutgers.edu
Key Words	Primary sclerosing cholangitis; Cholestasis; Inflammatory bowel disease; Autoimmune; Gallbladder neoplasia; Cholangiocarcinoma; IgG4 related disease; Colon cancer; Liver transplant
Core Tip	Primary sclerosing cholangitis (PSC) is a fascinating disease with numerous and overlapping theorized pathogenetic models. An autoimmune etiology is in part due to its association with inflammatory bowel disease and autoimmune hepatitis, and inclusion within the IgG4 spectrum of diseases. Though PSC has been documented in the literature for more than a century, only sparse details exist regarding its true pathogenetics and even less about successful medical therapy. More rigorous research is needed to truly understand and treat this disease entity.
Publish Date	2017-04-14 18:51
Citation	Gidwaney NG, Pawa S, Das KM. Pathogenesis and clinical spectrum of primary sclerosing cholangitis. World J Gastroenterol 2017; 23(14): 2459-2469
URL	http://www. wjgnet.com/1007-9327/full/v23/i14/2459.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i14.2459

Full Article (PDF)	WJG-23-2459.pdf
Full Article (Word)	WJG-23-2459.doc
Manuscript File	30961-Review.doc
Answering Reviewers	30961-Answering reviewers.pdf
Audio Core Tip	30961-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	30961-Conflict-of-interest statement.pdf
Copyright License Agreement	30961-Copyright assignment.pdf
Peer-review Report	30961-Peer-review(s).pdf
Scientific Misconduct Check	30961-Scientific misconduct check.pdf
Scientific Editor Work List	30961-Scientific editor work list.pdf