Publication Name	World Journal of Orthopedics
Manuscript ID	30969
Country	Italy

Received	2016-10-25 09:08
Peer-Review Started	2016-10-28 09:25
To Make the First Decision	2016-12-01 14:21
Return for Revision	2016-12-07 08:44
Revised	2017-01-05 05:05
Second Decision	2017-03-02 16:14
Accepted by Journal Editor-in-Chief	2017-03-02 23:41
Accepted by Company Editor-in-Chief	2017-03-13 11:32
Articles in Press	2017-03-13 11:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-09 15:06
Publish the Manuscript Online	2017-05-12 13:42

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Orthopedics
Manuscript Type	Systematic Reviews
Article Title	Predicting lower limb periprosthetic joint infections: A review of risk factors and their classification
Manuscript Source	Invited Manuscript
All Author List	David A George, Lorenzo Drago, Sara Scarponi, Enrico Gallazzi, Fares S Haddad and Carlo L Romano
Funding Agency and Grant Number
Corresponding Author	Dr. David A George, Specialist Registrar, Department of Trauma and Orthopaedic, University College London Hospital, 235 Euston Road, London NW1 2BU, United Kingdom. davidgeorge@doctors.org.uk
Key Words	Periprosthetic joint infection; Risk factor; Predictive; Hip arthroplasty; Knee arthroplasty
Core Tip	This systematic review determines the most statistically significant factors that increase a patient’s risk of developing lower limb periprosthetic joint infections. Reviewing all relevant papers until November 2016 through international databases, we have included 27 original studies. The results include multiple factors relating to the patient and the Institute, as well as post-operative predictors and causes of infection. This ultimately reiterates the importance of optimising the patients pre-operatively by addressing modifiable risk factors (such as their immunosuppression, nutrition, diabetes, and smoking), and develops strategies to limit the impact of non-modifiable factors.
Publish Date	2017-05-12 13:42
Citation	George DA, Drago L, Scarponi S, Gallazzi E, Haddad FS, Romano CL. Predicting lower limb periprosthetic joint infections: A review of risk factors and their classification. World J Orthop 2017; 8(5): 400-411
URL	http://www.wjgnet.com/2218-5836/full/v8/i5/400.htm
DOI	http://dx.doi.org/10.5312/wjo.v8.i5.400

Full Article (PDF)	WJO-8-400.pdf
Full Article (Word)	WJO-8-400.doc
Manuscript File	30969-Review.doc
Answering Reviewers	30969-Answering reviewers.pdf
Audio Core Tip	30969-Audio core tip.mp3
Biostatistics Review Certificate	30969-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	30969-Conflict-of-interest statement.pdf
Copyright License Agreement	30969-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20161025041428.doc
Supplementary Material	Supplementary_Material_20161025041357.docx
Peer-review Report	30969-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	30969-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	30969-Scientific misconduct check.pdf
Scientific Editor Work List	30969-Scientific editor work list.pdf