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3/19/2017 6:44:00 PM | Browse: 785 | Download: 1431
Publication Name World Journal of Gastroenterology
Manuscript ID 31008
Country/Territory Colombia
Received
2016-10-27 14:05
Peer-Review Started
2016-10-27 20:58
To Make the First Decision
2016-11-09 08:13
Return for Revision
2016-11-11 16:40
Revised
2016-12-16 04:51
Second Decision
2017-02-06 14:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-02-08 09:35
Articles in Press
2017-02-08 09:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-03-06 17:14
Publish the Manuscript Online
2017-03-19 18:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Microbiology
Manuscript Type Basic Study
Article Title Effect of treatment failure on the CagA EPIYA motif in Helicobacter pylori strains from Colombian subjects
Manuscript Source Unsolicited Manuscript
All Author List Javier Andres Bustamante-Rengifo, Andres Jenuer Matta, Alvaro Jairo Pazos and Luis Eduardo Bravo
Funding Agency and Grant Number
Corresponding Author Javier Andres Bustamante-Rengifo, MSc, PhD, Department of Microbiology, School of Basic Science, Universidad del Valle, Street 4B N0 36-00, Building 116, Floor 5, Cali 760043, Colombia. javierandres.bustamante@gmail.com
Key Words Helicobacter pylori; RAPD-PCR; Treatment failure; EPIYA motifs; 3’ cagA variable region
Core Tip This study evaluated the effect of treatment failure on cagA and vacA genotypes in Helicobacter pylori (H. pylori) isolates. It was found, that unsuccessful treatment of H. pylori limits the colonization by low-virulence strains, resulting in partial and selective eradication in mixed infections. Also, acts on the cagA-positive strains inducing genetic rearrangements (deletion or acquisition of EPIYA motifs) that could alter the adherence of CagA protein to the epithelial cell membrane, the level of tyrosine phosphorylation and CagA multimerization, impacting its effects on cellular signaling. Finally, in some cases, may lead to the diver-gence of H. pylori cagA-positive sub-clones.
Publish Date 2017-03-19 18:45
Citation Bustamante-Rengifo JA, Matta AJ, Pazos AJ, Bravo LE. Effect of treatment failure on the CagA EPIYA motif in Helicobacter pylori strains from Colombian subjects. World J Gastroenterol 2017; 23(11): 1980-1989
URL http://www.wjgnet.com/1007-9327/full/v23/i11/1980.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i11.1980
Full Article (PDF) WJG-23-1980.pdf
Full Article (Word) WJG-23-1980.doc
Manuscript File 31008-Review.docx
Answering Reviewers 31008-Answering reviewers.pdf
Audio Core Tip 31008-Audio core tip.mp3
Biostatistics Review Certificate 31008-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 31008-Conflict-of-interest statement.pdf
Copyright License Agreement 31008-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20161026110158.pdf
Institutional Review Board Approval Form or Document 31008-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 31008-Language certificate.pdf
Peer-review Report 31008-Peer-review(s).pdf
Scientific Misconduct Check 31008-Scientific misconduct check.pdf
Scientific Editor Work List 31008-Scientific editor work list.pdf