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Articles Published Processes
3/19/2017 6:44:00 PM | Browse: 897 | Download: 1836
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Received |
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2016-10-27 14:05 |
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Peer-Review Started |
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2016-10-27 20:58 |
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To Make the First Decision |
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2016-11-09 08:13 |
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Return for Revision |
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2016-11-11 16:40 |
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Revised |
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2016-12-16 04:51 |
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Second Decision |
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2017-02-06 14:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-02-08 09:35 |
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Articles in Press |
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2017-02-08 09:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-03-06 17:14 |
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Publish the Manuscript Online |
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2017-03-19 18:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of treatment failure on the CagA EPIYA motif in Helicobacter pylori strains from Colombian subjects
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Javier Andres Bustamante-Rengifo, Andres Jenuer Matta, Alvaro Jairo Pazos and Luis Eduardo Bravo |
| Funding Agency and Grant Number |
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| Corresponding Author |
Javier Andres Bustamante-Rengifo, MSc, PhD, Department of Microbiology, School of Basic Science, Universidad del Valle, Street 4B N0 36-00, Building 116, Floor 5, Cali 760043, Colombia. javierandres.bustamante@gmail.com |
| Key Words |
Helicobacter pylori; RAPD-PCR; Treatment failure; EPIYA motifs; 3’ cagA variable region |
| Core Tip |
This study evaluated the effect of treatment failure on cagA and vacA genotypes in Helicobacter pylori (H. pylori) isolates. It was found, that unsuccessful treatment of H. pylori limits the colonization by low-virulence strains, resulting in partial and selective eradication in mixed infections. Also, acts on the cagA-positive strains inducing genetic rearrangements (deletion or acquisition of EPIYA motifs) that could alter the adherence of CagA protein to the epithelial cell membrane, the level of tyrosine phosphorylation and CagA multimerization, impacting its effects on cellular signaling. Finally, in some cases, may lead to the diver-gence of H. pylori cagA-positive sub-clones. |
| Publish Date |
2017-03-19 18:45 |
| Citation |
Bustamante-Rengifo JA, Matta AJ, Pazos AJ, Bravo LE. Effect of treatment failure on the CagA EPIYA motif in Helicobacter pylori strains from Colombian subjects. World J Gastroenterol 2017; 23(11): 1980-1989 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i11/1980.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i11.1980 |
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