Publication Name	World Journal of Gastroenterology
Manuscript ID	31014
Country	China

Received	2016-10-27 12:14
Peer-Review Started	2016-10-27 21:27
To Make the First Decision	2016-12-01 15:42
Return for Revision	2016-12-02 17:19
Revised	2016-12-16 23:16
Second Decision	2016-12-29 10:50
Accepted by Journal Editor-in-Chief	2017-01-01 01:58
Accepted by Company Editor-in-Chief	2017-01-04 16:31
Articles in Press	2017-01-04 16:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-01-19 14:44
Typeset the Manuscript	2017-02-14 20:25
Publish the Manuscript Online	2017-02-26 18:20

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Prognostic significance of preoperative and postoperative CK19 and CEA mRNA levels in peripheral blood of patients with gastric cardia cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Feng Qiao, Chuan-Gui Chen, Jie Yue, Ming-Quan Ma, Zhao Ma and Zhen-Tao Yu
Funding Agency and Grant Number	Funding Agency Grant Number the National Key Clinical Specialist Construction Programs of China 2013-544 Science and Technology Development Fund of Tianjin Education Commission for Higher Education 20130121
Corresponding Author	Zhen-Tao Yu, MD, PhD, Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Huanhuxi Road, Tiyuanbei, HeXi District, Tianjin 300060, China. qyf800117@sina.com
Key Words	Gastric cardia cancer; Cytokeratin 19; Carcinoembryonic antigen; Clinicopathological factor; Prognosis
Core Tip	This is a retrospective study that evaluated the clinical and prognostic significance of the preoperative (pre-) and postoperative (post-) mRNA levels of cytokeratin 19 (CK19) and carcinoembryonic antigen (CEA) in peripheral blood of patients with gastric cardia cancer. Increased pre- and post-CK19 and CEA mRNA levels were associated with positive lymph node metastasis. Elevated pre- but not post-CK19 and CEA mRNA levels were independent prognostic factors for overall survival (OS). A new prognostic model was established based on independent prognostic factors (lymph node status, pre-CK19 and pre-CEA mRNA levels), and there was a significant difference in OS among the three different risk groups.
Publish Date	2017-02-26 18:20
Citation	Qiao YF, Chen CG, Yue J, Ma MQ, Ma Z, Yu ZT. Prognostic significance of preoperative and postoperative CK19 and CEA mRNA levels in peripheral blood of patients with gastric cardia cancer. World J Gastroenterol 2017; 23(8): 1424-1433
URL	http://www.wjgnet.com/1007-9327/full/v23/i8/1424.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i8.1424

Full Article (PDF)	WJG-23-1424.pdf
Full Article (Word)	WJG-23-1424.doc
Manuscript File	31014-Review.doc
Answering Reviewers	31014-Answering reviewers.pdf
Audio Core Tip	31014-Audio core tip.mp3
Biostatistics Review Certificate	31014-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	31014-Conflict-of-interest statement.pdf
Copyright License Agreement	31014-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	31014-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	31014-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	31014-Language certificate.pdf
Peer-review Report	31014-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	31014-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	31014-Scientific misconduct check.pdf
Scientific Editor Work List	31014-Scientific editor work list.pdf