Publication Name	World Journal of Gastroenterology
Manuscript ID	31021
Country	Italy

Received	2016-10-27 10:50
Peer-Review Started	2016-10-28 08:38
To Make the First Decision	2016-12-19 11:02
Return for Revision	2016-12-20 11:09
Revised	2017-01-19 19:17
Second Decision	2017-02-06 14:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-02-08 09:37
Articles in Press	2017-02-08 09:37
Publication Fee Transferred	2017-05-24 06:36
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-08 07:21
Publish the Manuscript Online	2017-06-14 09:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of non-steroidal anti-inflammatory drugs on intestinal permeability and nonalcoholic fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Erika Utzeri and Paolo Usai
Funding Agency and Grant Number
Corresponding Author	Paolo Usai, Associate Professor, Department of Medical Sciences, University of Cagliari, Via Università, 40, 09124 Cagliari, Italy. usaip@medicina.unica.it
Key Words	Non-steroidal anti-inflammatory drugs; Intestinal barrier; Intestinal permeability; Non-steroidal anti-inflammatory drugs - enteropathy; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Microbiota; Metabolic syndrome; Proton pump inhibitors; Endotoxaemia
Core Tip	Among the gastro-intestinal effects, in non-steroidal anti-inflammatory drugs (NSAIDs) users, those of the lower tract seem to be rising. NSAIDs enteropathy is due to the enterohepatic recycling of drugs, resulting in a prolonged and repeated exposure of the intestinal mucosa to the compound and its metabolites, leading to so called topical effects. The impairment of the intestinal barrier represents the initial damage of NSAIDs enteropathy that leads to the translocation of bacteria and toxic substances of intestinal origin in the portal circulation, promoting an endotoxaemia. This condition, mostly in patients with risk factors for nonalcoholic fatty liver diseas, such as obesity and metabolic syndrome, might lead to liver inflammatory response that could promote the development of nonalcoholic steatohepatitis.
Publish Date	2017-06-14 09:25
Citation	Utzeri E, Usai P. Role of non-steroidal anti-inflammatory drugs on intestinal permeability and nonalcoholic fatty liver disease. World J Gastroenterol 2017; 23(22): 3954-3963
URL	http://www.wjgnet.com/1007-9327/full/v23/i22/3954.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i22.3954

Full Article (PDF)	WJG-23-3954.pdf
Full Article (Word)	WJG-23-3954.doc
Manuscript File	31021-Review.doc
Answering Reviewers	31021-Answering reviewers.pdf
Audio Core Tip	31021-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	31021-Conflict-of-interest statement.pdf
Copyright License Agreement	31021-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	31021-Language certificate.pdf
Peer-review Report	31021-Peer-review(s).pdf
Scientific Misconduct Check	31021-Scientific misconduct check.pdf
Scientific Editor Work List	31021-Scientific editor work list.pdf