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6/14/2017 9:25:57 AM | Browse: 318 | Download: 260
Publication Name World Journal of Gastroenterology
Manuscript ID 31021
Country of Manuscript Source Italy
Received
2016-10-27 10:50
Peer-Review Started
2016-10-28 08:38
To Make the First Decision
2016-12-19 11:02
Return for Revision
2016-12-20 11:09
Revised
2017-01-19 19:17
Second Decision
2017-02-06 14:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-02-08 09:37
Articles in Press
2017-02-08 09:37
Publication Fee Transferred
2017-05-24 06:36
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-06-08 07:21
Publish the Manuscript Online
2017-06-14 09:25
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Review
Article Title Role of non-steroidal anti-inflammatory drugs on intestinal permeability and nonalcoholic fatty liver disease
Manuscript Source Unsolicited Manuscript
All Author List Erika Utzeri and Paolo Usai
Funding Agency and Grant Number
Corresponding author Paolo Usai, Associate Professor, Department of Medical Sciences, University of Cagliari, Via Università, 40, 09124 Cagliari, Italy. usaip@medicina.unica.it
Keywords Non-steroidal anti-inflammatory drugs; Intestinal barrier; Intestinal permeability; Non-steroidal anti-inflammatory drugs - enteropathy; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Microbiota; Metabolic syndrome; Proton pump inhibitors; Endotoxaemia
Core Tip Among the gastro-intestinal effects, in non-steroidal anti-inflammatory drugs (NSAIDs) users, those of the lower tract seem to be rising. NSAIDs enteropathy is due to the enterohepatic recycling of drugs, resulting in a prolonged and repeated exposure of the intestinal mucosa to the compound and its metabolites, leading to so called topical effects. The impairment of the intestinal barrier represents the initial damage of NSAIDs enteropathy that leads to the translocation of bacteria and toxic substances of intestinal origin in the portal circulation, promoting an endotoxaemia. This condition, mostly in patients with risk factors for nonalcoholic fatty liver diseas, such as obesity and metabolic syndrome, might lead to liver inflammatory response that could promote the development of nonalcoholic steatohepatitis.
Publish Date 2017-06-14 09:25
Citation Utzeri E, Usai P. Role of non-steroidal anti-inflammatory drugs on intestinal permeability and nonalcoholic fatty liver disease. World J Gastroenterol 2017; 23(22): 3954-3963
Url http://www.wjgnet.com/1007-9327/full/v23/i22/3954.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i22.3954
Full Article (PDF) WJG-23-3954.pdf
Full Article (Word) WJG-23-3954.doc
Manuscript File 31021-Review.doc
Answering Reviewers 31021-Answering reviewers.pdf
Audio Core Tip 31021-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 31021-Conflict-of-interest statement.pdf
Copyright License Agreement 31021-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 31021-Language certificate.pdf
Peer-review Report 31021-Peer-review(s).pdf
Scientific Misconduct Check 31021-Scientific misconduct check.pdf
Scientific Editor Work List 31021-Scientific editor work list.pdf