Publication Name	World Journal of Diabetes
Manuscript ID	31024
Country	United States

Received	2016-10-27 10:42
Peer-Review Started	2016-10-31 11:45
To Make the First Decision	2016-12-01 14:26
Return for Revision	2016-12-07 09:56
Revised	2017-04-13 14:51
Second Decision	2017-04-14 10:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-04-24 17:26
Articles in Press	2017-04-24 17:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-04 07:20
Publish the Manuscript Online	2017-06-15 02:07

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Field of Vision
Article Title	Statins redux: A re-assessment of how statins lower plasma cholesterol
Manuscript Source	Invited Manuscript
All Author List	Rajendra Raghow
Funding Agency and Grant Number
Corresponding Author	Rajendra Raghow, PhD, Professor, Department of Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, United States. rraghow@uthsc.edu
Key Words	Statins; Atorvastatin; Lovastatin; Rosuvasta­tin; Cholesterol synthesis; Hydroxyl-methyl glutaryl-CoA reductase
Core Tip	Schonewille et al, comprehensively studied cholesterol metabolism (de-novo synthesis of cholesterol and its inter-organ flux, and fecal elimination) in mice treated with rosuvastatin, atorvastatin or lovastatin. These analyses revealed that the rates of whole body and organ-specific cholesterol synthesis were boosted by all three statins. Mice treated with statins also elicited enhanced rates of biliary excretion of cholesterol and its fecal elimination. Remarkably, the process of trans-intestinal cholesterol excretion was augmented by only atorvastatin. These data shed mechanistic light on how statin treatment led to organ-specific metabolic adaptations in mice to reset their cholesterol homeostasis.
Publish Date	2017-06-15 02:07
Citation	Raghow R. Statins redux: a re-assessment of how statins lower plasma cholesterol. World J Diabetes 2017; 8(6): 230-234
URL	http://www.wjgnet.com/1948-9358/full/v8/i6/230.htm
DOI	http://dx.doi.org/10.4239/wjd.v8.i6.230

Full Article (PDF)	WJD-8-230.pdf
Full Article (Word)	WJD-8-230.doc
Manuscript File	31024-Review.docx
Answering Reviewers	31024-Answering reviewers.pdf
Audio Core Tip	31024-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	31024-Conflict-of-interest statement.pdf
Copyright License Agreement	31024-Copyright assignment.pdf
Peer-review Report	31024-Peer-review(s).pdf
Scientific Misconduct Check	31024-Scientific misconduct check.pdf
Scientific Editor Work List	31024-Scientific editor work list.pdf