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Articles Published Processes
5/17/2017 6:29:40 AM | Browse: 1393 | Download: 1953
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Received |
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2016-10-27 10:04 |
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Peer-Review Started |
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2016-10-31 13:24 |
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To Make the First Decision |
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2016-12-01 14:26 |
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Return for Revision |
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2016-12-07 10:04 |
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Revised |
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2017-02-21 04:06 |
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Second Decision |
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2017-04-14 10:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-04-24 17:27 |
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Articles in Press |
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2017-04-24 17:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-05-12 17:13 |
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Publish the Manuscript Online |
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2017-05-17 06:29 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Evidence-Based Medicine |
| Article Title |
Protein tolerance to standard and high protein meals in patients with liver cirrhosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Octavio Campollo, Dirk Sprengers, Gitte Dam, Hendrik Vilstrup and Neil McIntyre |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Octavio Campollo, Professor and researcher, Center of studies on Alcohol and Addictions, Antigüo Hospital Civil de Guadalajara, Universidad de Guadalajara, Calle Hospital 278, Col. El Retiro, Guadalajara, Jal CP 44280, Mexico. calcohol@hotmail.com |
| Key Words |
branched chain amino acids; Fischer’s ratio; liver; protein; cirrhosis; tolerance; nutrition; amino acids; diet |
| Core Tip |
In this study we investigated the plasma amino acid response to standard and high protein meals in patients with liver cirrhosis and looked for evidence of protein intolerance by testing for the presence of either covert or overt hepatic encephalopathy. We sought to improve on previous methodology by selecting a more homogeneous group of patients with biopsy proven cirrhosis, and by using natural mixed protein meals at two protein levels: A standard (20 g) meal and a high (1 g/kg per body weight) protein meal. We found small differences in the plasma amino acid changes after the standard protein meal but there were marked increments in most amino acids after the high protein meal. Noteworthy no patient showed overt clinical sings of encephalopathy and minor electroencephalo-graph changes were seen in only one patient after the high protein meal. These results present experimental evidence to support current nutritional guidelines for patients with cirrhosis. |
| Publish Date |
2017-05-17 06:29 |
| Citation |
Campollo O, Sprengers D, Dam G, Vilstrup H, McIntyre N. Protein tolerance to standard and high protein meals in patients with liver cirrhosis. World J Hepatol 2017; 9(14): 667-676 |
| URL |
http://www.wjgnet.com/1948-5182/full/v9/i14/667.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v9.i14.667 |
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