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Publication Name World Journal of Hepatology
Manuscript ID 31030
Country of Manuscript Source Mexico
2016-10-27 10:04
Peer-Review Started
2016-10-31 13:24
To Make the First Decision
2016-12-01 14:26
Return for Revision
2016-12-07 10:04
2017-02-21 04:06
Second Decision
2017-04-14 10:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-04-24 17:27
Articles in Press
2017-04-24 17:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-05-12 17:13
Publish the Manuscript Online
2017-05-17 06:29
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Evidence-Based Medicine
Article Title Protein tolerance to standard and high protein meals in patients with liver cirrhosis
Manuscript Source Invited Manuscript
All Author List Octavio Campollo, Dirk Sprengers, Gitte Dam, Hendrik Vilstrup and Neil McIntyre
Funding Agency and Grant Number
Corresponding author Dr. Octavio Campollo, Professor and researcher, Center of studies on Alcohol and Addictions, Antigüo Hospital Civil de Guadalajara, Universidad de Gua­dalajara, Calle Hospital 278, Col. El Retiro, Guadalajara, Jal CP 44280, Mexico. calcohol@hotmail.com
Keywords branched chain amino acids; Fischer’s ratio; liver; protein; cirrhosis; tolerance; nutrition; amino acids; diet
Core Tip In this study we investigated the plasma amino acid response to standard and high protein meals in patients with liver cirrhosis and looked for evidence of protein intolerance by testing for the presence of either covert or overt hepatic encephalopathy. We sought to improve on previous methodology by selecting a more homogeneous group of patients with biopsy proven cirrhosis, and by using natural mixed protein meals at two protein levels: A standard (20 g) meal and a high (1 g/kg per body weight) protein meal. We found small differences in the plasma amino acid changes after the standard protein meal but there were marked increments in most amino acids after the high protein meal. Noteworthy no patient showed overt clinical sings of encephalopathy and minor electroencephalo-graph changes were seen in only one patient after the high protein meal. These results present experimental evidence to support current nutritional guidelines for patients with cirrhosis.
Publish Date 2017-05-17 06:29
Citation Campollo O, Sprengers D, Dam G, Vilstrup H, McIntyre N. Protein tolerance to standard and high protein meals in patients with liver cirrhosis. World J Hepatol 2017; 9(14): 667-676
Url http://www.wjgnet.com/1948-5182/full/v9/i14/667.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i14.667
Full Article (PDF) WJH-9-667.pdf
Full Article (Word) WJH-9-667.doc
Manuscript File 31030-Review.docx
Answering Reviewers 31030-Answering reviewers.pdf
Audio Core Tip 31030-Audio core tip.m4a
Biostatistics Review Certificate 31030-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 31030-Conflict-of-interest statement.pdf
Copyright License Agreement 31030-Copyright assignment.pdf
Data Sharing Statement 31030-Data sharing statement.pdf
Peer-review Report 31030-Peer-review(s).pdf
Scientific Misconduct Check 31030-Scientific misconduct check.pdf
Scientific Editor Work List 31030-Scientific editor work list.pdf