Publication Name	World Journal of Gastroenterology
Manuscript ID	31116
Country	Canada

Received	2016-10-31 10:55
Peer-Review Started	2016-11-02 15:59
First Decision by Editorial Office Director
Return for Revision	2016-12-24 17:13
Revised	2017-01-17 06:22
Publication Fee Transferred
Second Decision by Editor	2017-03-09 17:52
Second Decision by Editor-in-Chief	2017-03-10 07:14
Final Decision by Editorial Office Director	2017-03-15 13:33
Articles in Press	2017-03-15 13:33
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-31 18:02
Publish the Manuscript Online	2017-04-06 18:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	What is the quantitative risk of gastric cancer in the first-degree relatives of patients? A meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Mohammad Yaghoobi, Julia McNabb-Baltar, Raheleh Bijarchi and Richard H Hunt
Funding Agency and Grant Number
Corresponding Author	Mohammad Yaghoobi, MD, MSc, AFS, FRCPC, Division of Gastroenterology, Division of Gastroenterology, McMaster University, Hamilton, ON L8S 4K1, Canada. yaghoob@mcmaster.ca
Key Words	Gastric cancer; Risk, Relatives; Family history; Meta-analysis
Core Tip	Several case-control studies have found a familial predisposition for gastric cancer. Most studies suggest that first-degree relatives of patients with gastric cancer are at higher risk. In this meta-analysis we aimed to quantify this risk by including case-control trials comparing the frequency of a positive family history of gastric cancer in patients with gastric cancer, versus non-gastric cancer controls were retrieved. We showed that the pooled relative risk for the development of gastric cancer in association with a positive family history was 2.35 (95%CI: 1.96-2.81). We concluded that the individuals with a first-degree relative affected with gastric cancer have a risk of about 2.5-fold for the development of gastric cancer. This could be due to genetic or environmental factors. Screening and preventive strategies should be developed for this high-risk population.
Publish Date	2017-04-06 18:30
Citation	Yaghoobi M, McNabb-Baltar J, Bijarchi R, Hunt RH. What is the quantitative risk of gastric cancer in the first-degree relatives of patients? A meta-analysis. World J Gastroenterol 2017; 23(13): 2435-2442
URL	http://www.wjgnet.com/1007-9327/full/v23/i13/2435.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i13.2435

Full Article (PDF)	WJG-23-2435.pdf
Full Article (Word)	WJG-23-2435.doc
Manuscript File	31116-Review.doc
Answering Reviewers	31116-Answering reviewers.pdf
Audio Core Tip	31116-Audio core tip.wav
Conflict-of-Interest Disclosure Form	31116-Conflict-of-interest statement.pdf
Copyright License Agreement	31116-Copyright assignment.pdf
Peer-review Report	31116-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	31116-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	31116-Scientific misconduct check.pdf
Scientific Editor Work List	31116-Scientific editor work list.pdf